LIPID MAPS

LIPID MAPS (Lipid Metabolites and Pathways Strategy) is a web portal designed to be a gateway to Lipidomics resources. The resource has spearheaded a classification of biological lipids, dividing them into eight general categories.[1] LIPID MAPS provides standardised methodologies for mass spectrometry analysis of lipids, e.g. [2][3][4]

LIPID MAPS
Content
DescriptionLipidomics
Contact
Primary citationPMID 17584797
Release date2003
Access
Websitewww.lipidmaps.org

LIPID MAPS has been cited as evidence of a growing appreciation of the study of lipid metabolism[5] and the rapid development and standardisation of the lipidomics field [6][7]

Key LIPID MAPS resources include:

  • LIPID MAPS Structure Database (LMSD) - a database of structures and annotations of biologically relevant lipids,[8] containing over 46000 different lipids. The paper describing this resource has, according to PubMed, been cited more than 200 times.
  • LIPID MAPS In-Silico Structure Database (LMISSD) - a database of computationally predicted lipids generated by expansion of headgroups for commonly occurring lipid classes
  • LIPID MAPS Gene/Proteome Database (LMPD) - a database of genes and gene products which are involved in lipid metabolism[9]

Tools available from LIPID MAPS enable scientists to identify likely lipids in their samples from mass spectrometry data, a common method to analyse lipids in biological specimens. In particular, LipidFinder [10] enables analysis of MS data. Tutorials and educational material on lipids are also available at the site.[11]

In January 2020, LIPID MAPS became an ELIXIR service.[12]

History

LIPID MAPS was founded in 2003 with NIH funding.[13] Since 2016, it has been a joint project between the University of Cardiff led by Prof Valerie O'Donnell, the Babraham Institute under Michael Wakelam, and UCSD scientists Shankar Subramaniam and Ed Dennis funded by the Wellcome Trust. Wakelam's obituary describes LIPID MAPS as unifying the field of lipidomics.[14]

LIPID MAPS is sponsored by Avanti Polar lipids and Cayman Chemicals

References
  1. Fahy E, Subramaniam S, Murphy RC, Nishijima M, Raetz CR, Shimizu T, Spener F, van Meer G, Wakelam MJ, Dennis EA (April 2009). "Update of the LIPID MAPS comprehensive classification system for lipids". Journal of Lipid Research. 50 Suppl (S1): S9-14. doi:10.1194/jlr.R800095-JLR200. PMC 2674711. PMID 19098281.
  2. Valeria Pereira Serafim P, Figueiredo JR, de Adiel G, Vitor Felipe A, Guimaraes Lo Turco E, Silva, Manoukian Forones N (2019). "STUDY OF LIPID BIOMARKERS OF PATIENTS WITH POLYPS AND COLORECTAL CÂNCER". Arquivos de Gastroenterologia. 56 (4): 399–404. doi:10.1590/S0004-2803.201900000-80. PMID 31800736.
  3. Zheng H, Yang R, Wang Z, Wang J, Zhang J, Sun H (2020). "Characterization of pharmaceutic structured triacylglycerols by high‐performance liquid chromatography/tandem high‐resolution mass spectrometry and its application to structured fat emulsion injection". Rapid Communications in Mass Spectrometry. 34 (1): e8557. doi:10.1002/rcm.8557. PMID 31429125.
  4. Sasaki H, White SH (2008). "Aggregation Behavior of an Ultra-Pure Lipopolysaccharide that Stimulates TLR-4 Receptors". Biophysical Journal. 95 (2): 986–993. Bibcode:2008BpJ....95..986S. doi:10.1529/biophysj.108.129197. PMC 2440428. PMID 18375521.
  5. Muralikrishna Adibhatla R, Hatcher JF (2007). "Role of lipids in brain injury and diseases". Future Lipidology. 2 (4): 403–422. doi:10.2217/17460875.2.4.403. PMC 2174836. PMID 18176634.
  6. "Phat on potential, lipidomics is gaining weight". Eureka Alert. 10 January 2019. Retrieved 10 June 2020.
  7. "Lipidomics – A Niche but Rapidly Growing Field". Technology Networks. 11 September 2019. Retrieved 10 June 2020.
  8. Sud M, Fahy E, Cotter D, et al. (January 2007). "LMSD: LIPID MAPS structure database". Nucleic Acids Res. 35 (Database issue): D527–32. doi:10.1093/nar/gkl838. PMC 1669719. PMID 17098933.
  9. Cotter D, Maer A, Guda C, Saunders B, Subramaniam S (January 2006). "LMPD: LIPID MAPS proteome database". Nucleic Acids Res. 34 (90001): D507–10. doi:10.1093/nar/gkj122. PMC 1347484. PMID 16381922.
  10. Fahy E, Alvarez-Jarreta J, Brasher CJ, Nguyen A, Hawksworth JI, Rodrigues P, Meckelmann S, Allen SM, O'Donnell VB (2019). "LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics". Bioinformatics. 35 (4): 685–687. doi:10.1093/bioinformatics/bty679. PMC 6378932. PMID 30101336.
  11. Sud M, Fahy E, Cotter D, Dennis EA, Subramaniam S (December 2011). "LIPID MAPS-Nature Lipidomics Gateway: An Online Resource for Students and Educators Interested in Lipids". Journal of Chemical Education. 89 (2): 291–292. doi:10.1021/ed200088u. PMC 3995124. PMID 24764601.
  12. "Service list". elixir-europe.org. Retrieved 10 June 2020.
  13. Conroy, Matthew J; Andrews, Robert M; Andrews, Simon; Cockayne, Lauren; Dennis, Edward A; Fahy, Eoin; Gaud, Caroline; Griffiths, William J; Jukes, Geoff; Kolchin, Maksim; Mendivelso, Karla; Lopez-Clavijo, Andrea F; Ready, Caroline; Subramaniam, Shankar; O’Donnell, Valerie B (19 October 2023). "LIPID MAPS: update to databases and tools for the lipidomics community". Nucleic Acids Research. doi:10.1093/nar/gkad896.
  14. Ferry, Georgina (24 April 2020). "Michael Wakelam obituary". The Guardian. Manchester. Retrieved 10 June 2020.
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