Kurkinorin

Kurkinorin is a non-nitrogenous, extremely selective centrally acting μ-opioid receptor agonist derived from salvinorin A[1] with no sedating or rewarding effects.[2]

Kurkinorin
Names
IUPAC name
Methyl (2S,4aR,6aR,7R,10aR,10bR)-9-benzoyloxy-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,10a-hexahydro-1H-benzo[f]isochromene-7-carboxylate
Identifiers
3D model (JSmol)
  • InChI=1S/C28H28O8/c1-27-11-9-18-26(32)36-21(17-10-12-34-15-17)14-28(18,2)23(27)22(29)20(13-19(27)25(31)33-3)35-24(30)16-7-5-4-6-8-16/h4-8,10,12-13,15,18-19,21,23H,9,11,14H2,1-3H3/t18-,19-,21-,23-,27-,28-/m0/s1
    Key: PJQKOFKRIYWHQP-JXSGGZGWSA-N
  • C[C@@]12CC[C@H]3C(=O)O[C@@H](C[C@@]3([C@H]1C(=O)C(=C[C@H]2C(=O)OC)OC(=O)C4=CC=CC=C4)C)C5=COC=C5
Properties
C28H28O8
Molar mass 492.524 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

See also

References
  1. Crowley RS, Riley AP, Alder AF, Anderson RJ, Luo D, Kaska S, Maynez P, Kivell BM, Prisinzano TE (June 2020). "Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the μ-Opioid Receptor". ACS Chemical Neuroscience. 11 (12): 1781–1790. doi:10.1021/acschemneuro.0c00191. PMC 7359744. PMID 32383854.
  2. Shivaperumal, Nirajmohan (May 18, 2017). Investigating the analgesic properties of Kurkinorin, a novel mu-opioid receptor analogue of Salvinorin A (Masters). Victoria University of Wellington.
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