Katrina Miranda

Katrina Miranda is an associate professor of biochemistry at the University of Arizona. She works on nitric oxide and their role in diseases like breast cancer, stroke and chronic pain.

Katrina Miranda
Alma materNorthern Arizona University
University of California, Santa Barbara
AwardsPECASE (2008)
Scientific career
InstitutionsUniversity of Arizona
National Cancer Institute
University of New Mexico School of Medicine

Early life and education

Miranda studied chemistry at Northern Arizona University.[1] She moved to the University of California, Santa Barbara, and earned her PhD in 1996.[1] Miranda was a postdoctoral fellow at the University of New Mexico School of Medicine.[1]

Research

Miranda studies the chemical and biological basis of redox signalling agents.[1][2] She was a National Institutes of Health postdoctoral fellow at the National Cancer Institute from 1998 to 2002, before joining the University of Arizona.[3] She looks to identify the biomarkers of disease development. They do this by investigating the molecular redox chemistry new donor systems and designing ways to detect biological signals.[1][4][5] Nitric oxide is synthesised in the body when L-Arginine enzymatically oxidises.[6] Miranda looked at what happens when nitric oxides accumulate, including their impact on chronic pain, strokes and breast cancer.[7] She demonstrated that nitric oxide can modify how enzymes bind to metal centres.[6] She studied the reactivity of azanone to clarify the activity of biomolecules.[8] She published the textbook Chemical Biology of Nitric Oxide in 2008.[9] Her research group attach chemical moieties that can improve drug delivery.[1] They are using gene expression, genomic and proteomic techniques to analyse the cellular effects of redox active signalling.[1]

Miranda runs outreach activities for faculty at the Arizona Community College to take part in research in her faculty.[8] In 2013 she developed a massive open online course with Google that would explain abstract chemistry concepts to students around the world.[10] In 2018 she filed a class action lawsuit against the University of Arizona for gender discrimination against women professors.[11] She is not the first to sue the University of Arizona; emeritus dean Patricia MacCorquodale and former dean Janice Cervelli took them to court on behalf of women deans in early 2018.[12]

Awards

References
  1. "Katrina Miranda | cbc.arizona.edu". cbc.arizona.edu. Retrieved 2018-12-11.
  2. Vázquez-Torres, Andrés (November 2012). "Redox Active Thiol Sensors of Oxidative and Nitrosative Stress". Antioxidants & Redox Signaling. 17 (9): 1201–1214. doi:10.1089/ars.2012.4522. ISSN 1523-0864. PMC 3430479. PMID 22257022.
  3. Blue, Alexis; Communications, University (5 January 2009). "Chemistry Professor Honored in Washington, D.C." UANews. Retrieved 2018-12-11.
  4. Cheng, Robert Y.S.; Basudhar, Debashree; Ridnour, Lisa A.; Heinecke, Julie L.; Kesarwala, Aparna H.; Glynn, Sharon; Switzer, Christopher H.; Ambs, Stefan; Miranda, Katrina M. (December 2014). "Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways". Nitric Oxide. 43: 17–28. doi:10.1016/j.niox.2014.08.003. ISSN 1089-8603. PMC 4250314. PMID 25153034.
  5. Johnson, Gail M.; Chozinski, Tyler J.; Gallagher, Elyssia S.; Aspinwall, Craig A.; Miranda, Katrina M. (November 2014). "Glutathione sulfinamide serves as a selective, endogenous biomarker for nitroxyl after exposure to therapeutic levels of donors". Free Radical Biology and Medicine. 76: 299–307. doi:10.1016/j.freeradbiomed.2014.07.022. ISSN 0891-5849. PMC 4254043. PMID 25064322.
  6. "Katrina M-Miranda | BIO5". www.bio5.org. Retrieved 2018-12-11.
  7. "Developing Anticancer Drugs | Benefunder". www.benefunder.com. Retrieved 2018-12-11.
  8. "The Presidential Early Career Award for Scientists and Engineers: Recipient Details | NSF - National Science Foundation". www.nsf.gov. Retrieved 2018-12-11.
  9. Miranda, Katrina (2008-03-31). Chemical Biology of Nitric Oxide (1st ed.). Garland Science. ISBN 9780815341475.
  10. "The University of Arizona Foundation - Gift Impact Article". www.uafoundation.org. Retrieved 2018-12-11.
  11. December 2018, Rebecca Trager11. "Chemistry prof sues for $20m over alleged gender discrimination". Chemistry World. Retrieved 2018-12-11.
  12. "U of Arizona is being sued once again for alleged discrimination against women in terms of salary and promotions". www.insidehighered.com. Retrieved 2018-12-11.

[1]

  1. Amarakoon, Thilini N.; Ke, Neng; Aspinwall, Craig A.; Miranda, Katrina M. (2022-01-01). "Quantification of intracellular HNO delivery with capillary zone electrophoresis". Nitric Oxide: Biology and Chemistry. 118: 49–58. doi:10.1016/j.niox.2021.10.005. ISSN 1089-8611. PMC 8758193. PMID 34715361.
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