Katherine O'Brien

Katherine "Kate" L. O'Brien (born 1963)[1] is a Canadian American pediatric infectious disease physician, epidemiologist, and vaccinologist who specializes in the areas of pneumococcal epidemiology, pneumococcal vaccine trials and impact studies, and surveillance for pneumococcal disease.[2] She is also known as an expert in infectious diseases (including pneumonia and diarrheal diseases) in American Indian populations. O’Brien is currently the Director of the World Health Organization's Department of Immunization, Vaccines and Biologicals.

Not to be confused with Katie O'Brien, Kathleen O'Brien, Kate O'Brien, Katharine O'Brien, or Cathy O'Brien.
Kate O'Brien
O'Brien with the Presidential Early Career Award for Scientists and Engineers (PECASE) award for 2010
Born1963 (age 59–60)
Edmonton, Alberta, Canada
NationalityCanadian American
EducationUniversity of Toronto
McGill University
Johns Hopkins Bloomberg School of Public Health
Occupation(s)Pediatric infectious disease physician
Epidemiologist
Vaccinologist
Years active1988-present
Children2

Early life and education

O'Brien was born in Edmonton, Alberta.[3] She grew up in Ottawa, in the province of Ontario, and graduated from Lisgar Collegiate Institute in 1980.

In 1984, O'Brien earned a BSc in chemistry from the University of Toronto. In 1988, O'Brien received an MD from McGill University at the age of 25 years old.[1] O'Brien came to the United States to do her residency in pediatric at Johns Hopkins Hospital from 1988 to 1991.[1][4] In 1994, O'Brien received an MPH from Johns Hopkins Bloomberg School of Public Health focused on International Public Health/International Health while also doing a two-year training program in pediatric infectious diseases.[1]

Career

In 1991, O'Brien worked for a year in Port-au-Prince, Haiti on a children's health project on HIV transmission.[1] She said the experience was formative, and led her to view vaccines as being a social justice issue.[4]

From 1995 to 1997, she worked at the Centers for Disease Control and Prevention (CDC) as an Epidemiologic Intelligence Officer in the Bacterial Respiratory Diseases Branch.

In 1996, as part of her job at the CDC, and given her previous experience in Haiti, O'Brien traveled to Haiti to investigate an outbreak of children who were dying.[5] O'Brien and colleague Joel Selanikio (from the CDC) discovered the children had been exposed to liquid acetaminophen Afebril and Valodon manufactured by Pharval that was contaminated with almost 25% diethylene glycol (DEG), a poison.[6][7] It was later discovered that there was contamination in the supply chain tracing back to a Chinese manufacturer.[8][9]

In July 1998, O'Brien joined the faculty of Johns Hopkins Bloomberg School of Public Health, eventually becoming a Professor of International Health and Epidemiology and Executive Director of the International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health.[2] Her scientific and policy work domestically and globally has focused on vaccine preventable illnesses, among both children and adults. The work has included surveillance, epidemiology, and vaccine clinical trials of pneumococcal disease; rotavirus; Haemophilus influenzae type b; respiratory syncytial virus and influenza vaccines. She has worked extensively with American Indian populations and in Africa and south Asia, partnering with local scientists and country program staff to develop rigorous scientific evidence and bring it into the vaccine policy arena, thereby accelerating the use and access to life-saving vaccines for children living in low resource countries and settings. She left Johns Hopkins in December 2018.

In January 2019, O'Brien became the director of the Immunization, Vaccines and Biologicals Department at the World Health Organization (WHO).[10] In this role, she is responsible for leading the overall work and strategy of the Department to advance the vision of reducing the health, social and economic burden of vaccine preventable diseases. The Director works across all levels of WHO (country, region and headquarters) in collaboration with partners to deliver country impact.[11]

She has worked in close partnerships with GAVI, the Vaccine Alliance, university colleagues, NGOs, and with countries to advance programs and policies on child health.

Personal life

O'Brien is married to an adult infectious disease physician who specializes in HIV/AIDs, who she met while working in Haiti.[12] They have a daughter and a son.[13]

Leadership

Awards
  • 1997: Food and Drug Administration, Group Recognition Award for meritorious service in the investigation of an international public health crisis which was associated with the contamination of pharmaceuticals by diethylene glycol
  • 1997: CDC, Group Honor Award for The Haiti Emergency Response Team
  • 1997: CDC, Donald C. Mackel Memorial Award for "Epidemic of Deaths from Acute Renal Failure Among Children in Haiti"[16]
  • 1998: United States Department of Health and Human Services, Secretary's Distinguished Service Award
  • 1999: CDC, James H. Nakano Citation for "Epidemic of Pediatric Deaths from Acute Renal Failure Caused by Diethylene Glycol Poisoning"
  • 2001: CDC, Honor Award for outstanding scientific contributions to public health, Group B Streptococcal Prevention Team
  • 2003: CDC, Outstanding Scientific Contribution to Public Health Award (nominee)
  • 2008: Sabin Vaccine Institute, Young Investigator Award[17][18]
  • 2011: National Institutes of Health, President's Early Career Award in Science and Engineering (PECASE)[19][20][21]
  • 2013: Robert Austrian Award and Lectureship
  • 2014: International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-9), Robert Austrian Lecturer
  • 2015: Maryland Women's Hall of Fame[3]

Selected works and publications

References
  1. Meman, Amelia (2015). "Katherine O'Brien, M.D., MSA SC 3520-17120". Maryland State Archives.
  2. "Faculty Directory: Katherine O'Brien". Johns Hopkins Bloomberg School of Public Health. Retrieved 27 May 2020.
  3. "Katherine O'Brien, M.D." Maryland Women's Hall of Fame. Maryland Commission for Women. 2015.
  4. Martin, Dr Nina M.; Sudarsan, Swati; O'Brien, Kate (22 November 2017). "Episode 52: Kate O'Brien On Vaccines & Social Justice". Public Health United.
  5. Pendergrast, Mark (2010). "Rough Sledding: Death in Haiti". Inside the Outbreaks: The Elite Medical Detectives of the Epidemic Intelligence Service. Boston: Mariner Books/Houghton Mifflin Harcourt. pp. 300–301. ISBN 978-0-547-48723-6. OCLC 988018975.
  6. Centers for Disease Control and Prevention (CDC) (2 August 1996). "Fatalities associated with ingestion of diethylene glycol-contaminated glycerin used to manufacture acetaminophen syrup--Haiti, November 1995-June 1996". MMWR. Morbidity and Mortality Weekly Report. 45 (30): 649–50. PMID 8769471. Wikidata ()
  7. O'Brien, KL; Selanikio, JD; Hecdivert, C; Placide, MF; Louis, M; Barr, DB; Barr, JR; Hospedales, CJ; Lewis, MJ; Schwartz, B; Philen, RM; St Victor, S; Espindola, J; Needham, LL; Denerville, K (15 April 1998). "Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. Acute Renal Failure Investigation Team". JAMA. 279 (15): 1175–80. doi:10.1001/JAMA.279.15.1175. PMID 9555756. Wikidata ()
  8. Barr, Dana B.; Barr, John R.; Weerasekera, Gayanga; Wamsley, Jacob; Kalb, Suzanne R.; Sjödin, Andreas; Schier, Joshua G.; Rentz, E. Danielle; Lewis, Lauren; Rubin, Carol; Needham, Larry L.; Jones, Robert L.; Sampson, Eric J. (July 2007). "Identification and Quantification of Diethylene Glycol in Pharmaceuticals Implicated in Poisoning Epidemics: An Historical Laboratory Perspective". Journal of Analytical Toxicology. 31 (6): 295–303. doi:10.1093/JAT/31.6.295. PMID 17725874. Wikidata ()
  9. Bogdanich, Walt (17 June 2007). "F.D.A. Tracked Poisoned Drugs, but Trail Went Cold in China". The New York Times.
  10. "Leadership: Universal Health Coverage (UHC) and Life Course". World Health Organization. Archived from the original on June 18, 2016. Retrieved 16 July 2019.
  11. "Immunization, Vaccines and Biologicals - Strategic Advisory Group of Experts (SAGE) on Immunization: Professor Katherine O'Brien". World Health Organization. 28 October 2013. Archived from the original on November 4, 2015.
  12. Healy, Kelly (19 November 2012). "IVAC Blog: A Conversation with Dr. Kate O'Brien". International Vaccine Access Center (IVAC). Johns Hopkins Bloomberg School of Public Health. Archived from the original on 30 November 2015.
  13. O'Brien, MD, Kate (9 November 2011). "Pneumonia kills babies: to protect them = vaccinate!". World Pneumonia Day. Archived from the original on 10 February 2012.
  14. "Kate O'Brien". GAVI. Retrieved 27 May 2020.
  15. "Katherine L O'Brien, Senior Advisor, Infectious Disease". Center for American Indian Health. Retrieved 27 May 2020.
  16. "Donald C. Mackel Memorial Award: Attending EIS Conference: Epidemic Intelligence Service". CDC. 27 September 2019.
  17. Wood-Wright, Natalie (6 May 2008). "Katherine O'Brien Receives Young Investigator Award". Johns Hopkins Bloomberg School of Public Health.
  18. "Malaria Vaccine Pioneer Awarded the Albert B. Sabin Gold Medal in Vaccinology". Sabin Vaccine Institute. 6 May 2008.
  19. "The Presidential Early Career Award for Scientists and Engineers (PECASE)". National Institutes of Health. 2010.
  20. "Katherine O'Brien". National Institutes of Health. 2010.
  21. Office of the Press Secretary (26 September 2011). "President Obama Honors Outstanding Early-Career Scientists". Whitehouse.gov.
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