Karen Miga

Karen Elizabeth Hayden Miga is an American geneticist who co-leads the Telomere-to-Telomore (T2T) consortium that released fully complete assembly of the human genome in March 2022.[1] She is an assistant professor of biomolecular engineering at the University of California, Santa Cruz and Associate Director of Human Pangenomics at the UC Santa Cruz Genomics Institute. She was named as "One to Watch" in the 2020 Nature's 10 and one of Time 100’s most influential people of 2022.

Karen H. Miga
Born
Karen Elizabeth Hayden
Known forTelomere to Telomere Project
Scientific career
InstitutionsUniversity of California, Santa Cruz
ThesisA Genomic Definition of Centromeres in Complex Genomes (2011)
Doctoral advisorHuntington Willard
Websitehttps://www.migalab.com/

Research and career

In 2012, Miga joined the laboratory of David Haussler at the University of California, Santa Cruz.[2] At UCSC she combined computational and experimental approaches.[3] There she leads the telomere-to-telomere (T2T) consortium,[3][4] a community based effort that seeks to fully sequence and assemble the human genome.[4] Her research efforts make use of long-read sequencing strategies.[4][5] She makes use of the Oxford Nanopore Technologies MinION sequencer, which analyses DNA by detecting changes in current flow when DNA passes through nanopores in a membrane.[5]

Miga is the director of the Human Pangenome Production Center that seeks to contribute to the next human pangenome reference map through the creation of 350 T2T diploid genomes.[4][6] This map will support the development of personalized therapeutics.[4]

Selected publications
  • Miga, Karen H.; Koren, Sergey; Rhie, Arang; Vollger, Mitchell R.; Gershman, Ariel; Bzikadze, Andrey; Brooks, Shelise; Howe, Edmund; Porubsky, David; Logsdon, Glennis A.; Schneider, Valerie A. (2020). "Telomere-to-telomere assembly of a complete human X chromosome". Nature. 585 (7823): 79–84. Bibcode:2020Natur.585...79M. doi:10.1038/s41586-020-2547-7. PMC 7484160. PMID 32663838.
  • Chimpanzee Sequencing Analysis Consortium (2005). "Initial sequence of the chimpanzee genome and comparison with the human genome". Nature. 437 (7055): 69–87. Bibcode:2005Natur.437...69.. doi:10.1038/nature04072. ISSN 0028-0836. PMID 16136131.
  • Rosenbloom, Kate R.; Armstrong, Joel; Barber, Galt P.; Casper, Jonathan; Clawson, Hiram; Diekhans, Mark; Dreszer, Timothy R.; Fujita, Pauline A.; Guruvadoo, Luvina; Haeussler, Maximilian; Harte, Rachel A. (2015-01-28). "The UCSC Genome Browser database: 2015 update". Nucleic Acids Research. 43 (D1): D670–D681. doi:10.1093/nar/gku1177. ISSN 0305-1048. PMC 4383971. PMID 25428374.
  • Jain, Miten; Koren, Sergey; Miga, Karen H.; Quick, Josh; Rand, Arthur C.; Sasani, Thomas A.; Tyson, John R.; Beggs, Andrew D.; Dilthey, Alexander T.; Fiddes, Ian T.; Malla, Sunir (2018). "Nanopore sequencing and assembly of a human genome with ultra-long reads". Nature Biotechnology. 36 (4): 338–345. doi:10.1038/nbt.4060. ISSN 1546-1696. PMC 5889714. PMID 29431738.

References
  1. "Researchers generate the first complete, gapless sequence of a human genome". Genome.gov. Retrieved 2023-02-07.
  2. "Speaker - Cell Symposia: 20 Years of the Human Genome: from Sequence to Substance". www.cell-symposia.com. Retrieved 2020-12-20.
  3. Isenberg, Sara (2019-10-23). "Are we there yet? Karen Miga on the Next Era of Genomics". Santa Cruz Tech Beat. Retrieved 2020-12-20.
  4. "Karen Miga | VIB Conferences". www.vibconferences.be. Retrieved 2020-12-20.
  5. "Scientists achieve first complete assembly of human X chromosome". EurekAlert!. Retrieved 2020-12-20.
  6. "Dawn of good, fast and cheap human genome assembly". ScienceDaily. Retrieved 2020-12-20.
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