Jaani Dushman: Ek Anokhi Kahani

Divya (Manisha Koirala) and Karan Saxena (Sunny Deol) are in love and engaged. Karan has a younger step-brother, Vivek (Sonu Nigam), whom he looks after as if he was his brother. Divya and Vivek study in the same college as their best-friends group. The group includes:

• Atul Agarwal (Akshay Kumar), who is dating Nita (Rambha) and is an atheist, Leader of Their Group
• Bodybuilder and boxer Vijay (Sunil Shetty), who is dating Preeti (Pinky Campbell).
• Vivek Saxena (Sonu Nigam), Atul's best friend and Karan's brother.
• Ashok Kejriwal (Aditya Pancholi), an extremely wealthy man who is dating Rashmi (Kiran Rathod)
• Prem Srivastava (Aftab Shivdasani), who is secretly in love with Rashmi.
• Victor (Sharad Kapoor), a photographer.
• Abdul (Arshad Warsi), who is always looking to crack a joke.
• Rajesh (Rajat Bedi), a mimicry artist and a womanizer who always lusts for Divya.
• Divya/Vasundhara (Manisha Koirala), the most beautiful girl in the college.

Two students named Rajesh and Madan (Sushant 'Siddharth' Ray) attempt to rape Divya. They are stopped and beaten up by Karan, who takes them to the college's principal, Professor Joseph. He agrees to let the incident go if Divya forgives them, which she later does. However, Rajesh and Madan decide to avenge their humiliation. Soon after, Karan goes to London for work. Divya then begins to have premonitions of a past life and later learns that her name was Vasundhara in a past life, and she was in love with Kapil (Armaan Kohli), a snake with magical powers. Their love life was shattered when they disturbed an angry sage (Amrish Puri) who cursed them with separation until the 21st century. Kapil had to undergo penance until the 21st century when Vasundhara will be reborn as Divya. He also gained supernatural strength, near-immortality, and the power to impersonate anything as a result of his penance. The sage warned him that he could be defeated or killed by someone with a supernatural and immortal being considered to be an equal opponent to Kapil.

Under the pretext of inviting Divya to Atul's party, Rajesh imitates the voices of all the guys in the group and tricks her into coming to an abandoned fort earlier than the scheduled time for the party. Divya arrives, where she is brutally raped by Rajesh and Madan, prompting her to kill herself. Divya's friends arrive, and she curses them, thinking that they were involved in the rape. Kapil learns of her death and promises to get his revenge on everyone in the group. As a result, Madan is killed the same night by Kapil. Divya is meanwhile reduced to a soul, who could enter human bodies and control them as per her wish. Rajesh gets married and his best friends arrive at the party. On that night, she enters the soul of his bride and kills him.

Kapil and Divya decide to kill everyone (everyone whose voice Rajesh had imitated) who coerced her to go to the fort. Kapil impersonates a driver who gives a lift to Victor when his car broke down. After isolating him, Kapil runs over Victor with a motorbike. He goes to the party in Lonavala impersonating Victor and kills Abdul by electrocuting him.

Atul and his friends, with the help of their Principal Joseph (Raj Babbar), a professor of parapsychology, summon Divya's ghost. They try to reason with Divya, explaining that they had never called her to the fort after she initially declined. However, she refuses to believe their innocence. The principal gives the group necklaces with higher powers and assures them that they cannot be harmed by supernatural forces when they are wearing the necklace. Atul, an atheist, doesn't believe this. However, when he is attacked by Kapil, he realizes he survived because the necklace was stuck in his hand. Later, Kapil impersonates Nita and badly injures Atul but couldn't kill him. He ends up in a coma.

Divya then enters Prem's body and kills his nemesis, Ashok. Prem is immediately arrested but could be set free based on Rashmi's false statement, which she is willing to give because she was also in love with Prem. However, Divya enters Rashmi's body and accuses Prem of the murder in court. A distraught Prem is sentenced to be hanged to death by the court.

Preeti's father wants her to marry his friend's boxer son Raju instead of Vijay. Her father and Raju collude and decide that Raju will kill Vijay in a boxing match to remove him from the picture. Divya enters Raju's body and almost knocks out Vijay. But the principal notices this and uses his paraphernalia to block Divya's presence. Divya doesn't let Kapil interfere, and Vijay knocks out Raju. Divya stopped Kapil as she wants to be the one killing Vijay since he was the one who informed her of the time to arrive at the fort that night. She exacts her revenge by entering Vijay's body, which leads him to jump off the terrace and die.

The death of all his friends scares Vivek, who calls Karan to return to Mumbai to protect him. Before Karan could arrive home, Kapil impersonates their college principal and tells him to throw off the locket, he then tries to kill him but scares him off. Kapil then impersonates Karan and stabs Vivek, but couldn't kill him after noticing Karan's arrival. Kapil escapes and a confused Karan is arrested after Vivek accuses him of the stabbing. Atul comes out of a coma and escapes the hospital with Vivek, who also recovered at the same hospital to kill Kapil. Atul is stabbed by Kapil while trying to save Vivek. Kapil then goes after Vivek. Atul, unable to destroy Kapil or save Vivek's life, goes to the principal and begs him to save Vivek's life. Atul then dies due to blood loss from his injuries.

Karan breaks out of the police lockup and shows up to stop Kapil from killing Vivek. Karan is fatally wounded by Kapil. Principal Joseph resurrects Karan with outer-world powers by merging all 4 religions of the world, granting him supernatural powers like Kapil. Karan finally kills Kapil. Vivek and Karan survive with Vivek being the only survivor among his best friends. Kapil and Vasundhara reunite in heaven.

• Sunny Deol as Karan Saxena, Vivek's elder brother.
• Suniel Shetty as Vijay
• Akshay Kumar as Atul Agarwal
• Sonu Nigam as Vivek Saxena / Vicky, Karan's younger brother.
• Arshad Warsi as Abdul
• Aftab Shivdasani as Prem Srivastava
• Aditya Pancholi as Ashok Kejriwal
• Manisha Koirala as Divya / Vasundhara snake woman
• Rambha as Nita, Atul's girlfriend.
• Kiran Rathod as Rashmi Sharma
• Armaan Kohli as Kapil snake man
• Siddharth Ray as Madan The Goon Negative role
• Sharad Kapoor as Victor
• Rajat Bedi as Rajesh The Goon Negative role
• Raj Babbar as Principal Joseph
• Kiran Kumar as a Police Inspector
• Raza Murad as Priti's father (special appearance)
• Shahbaaz Khan as Raju (cameo appearance)
• Jaspal Bhatti as Raju's Boxing manager (cameo appearance)
• Aman Verma as TV show host
• Shamsuddin as Javed in the song Javed Bhai So Re Le.
• Upasana Singh as Niki
• Ali Khan as Doctor
• Pinky Campbell as Priti
• Gavin Packard as Referee
• Amrish Puri as Sadhu (special appearance)
• Atul Agnihotri as a man driving in a red car. (cameo appearance)
• Dinesh Hingoo as a man in a car with his family. (cameo appearance)
• Preeti Bhutani
• Johnny Lever as Parwana

Salman Khan was the original choice for Sonu Nigam's role but declined the film because of date issues. Atul Agnihotri was initially signed for Sharad Kapoor's role in the film but later opted for a guest appearance, then the role went to Apurva Agnihotri but declined it due to date issues. Shah Rukh Khan was originally chosen to play Akshay Kumar's role but declined it because he was busy filming Kal Ho Naa Ho (2003) in New York City. Chandrachur Singh was first signed to play Aditya Pancholi's role but then he opted out. Shilpa Shetty was considered to play Manisha Koirala's role, but she declined the role. At one point when the film was announced, Ajay Devgn was supposed to play Suniel Shetty's role, Sanjay Dutt was going to be an extra character similar to his father Sunil Dutt's role in Nagin (1976) and Jackie Shroff playing Raj Babbar's role.

A star-studded cast was initially planned for this film featuring Sunny Deol, Shah Rukh Khan, Salman Khan, Ajay Devgn, Sanjay Dutt, Jackie Shroff, Chandrachur Singh, Apurva Agnihotri, Aftab Shivdasani, Arshad Warsi, Shilpa Shetty and Armaan Kohli but then the cast subsequently changed and it later starred Sunny Deol, Akshay Kumar, Suniel Shetty, Chandrachur Singh, Aftab Shivdasani, Arshad Warsi, Atul Agnihotri, Shilpa Shetty and Armaan Kohli. The film's theme was initially similar to that of Kohli's previous venture Nagin (1976) at that time, and the heroes were playing young mature men instead of college students later cast subsequently changed to Sunny Deol, Akshay Kumar, Sonu Nigam, Suniel Shetty, Aftab Shivdasani, Aditya Pancholi, Arshad Warsi, Sharad Kapoor, Manisha Koirala and Armaan Kohli in the lead role with a different subject.

Jaani Dushman: Ek Anokhi Kahaani opened well at the box office, collecting about ₹13.5 million on its first day. It collected ₹14 million on its second day and ₹12.7 million on its third day, taking its opening weekend collection to ₹40.2 million.

However, the negative critical reception led to a drastic fall in the box office collection. Its first-week collection closed at ₹64.7 million. Its collection continued declining, and finally ended up at a domestic net of ₹107.1 million, resulting in the film being declared a "Flop" by Box Office India.

The music for Jaani Dushman: Ek Anokhi Kahani was composed by Anand Raj Anand & Anand–Milind, with a guest composition by Sandeep Chowta. It was released on Universal Music. All tracks composed by Anand–Milind had lyrics penned by Sameer, whereas the tracks composed by Anand Raj Anand had lyrics written by Dev Kohli.

• Jaani Dushman: Ek Anokhi Kahani at IMDb