Issac
Issac may refer to:
Given name
    
- Issac Amaldas, Indian boxer
 - Issac Bailey, American writer
 - Issac Blakeney (born 1992), American football wide receiver
 - Issac Booth (born 1971), American football player
 - Issac Ryan Brown (born 2005), American child actor and singer
 - Issac Delgado (born 1962), Cuban-Spanish musician, and salsa performer
 - Issac Honey (born 1993), Ghanaian footballer
 - Issac Koga (1899–1982), Japanese electronics researcher/engineer
 - Issac Luke (born 1987), New Zealand rugby league hooker
 - Issac Osae (born 1993), Ghanaian footballer
 
Surname
    
- Osthatheos Issac (born 1976), Syriac Orthodox bishop
 - Rod Issac (born 1989), American football cornerback
 
Places
    
- Issac, Dordogne, a commune in France.
 
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