Isonocardicin synthase
In enzymology, an isonocardicin synthase (EC 2.5.1.38) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + nocardicin E 5'-methylthioadenosine + isonocardicin A
| isonocardicin synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.38 | ||||||||
| CAS no. | 118246-74-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and nocardicin E, whereas its two products are 5'-methylthioadenosine and isonocardicin A.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase. This enzyme is also called nocardicin aminocarboxypropyltransferase.
References
- Wilson BA, Bantia S, Salituro GM, Reeve AM, Townsend CA (1988). "Cell-free biosynthesis of nocardicin A from nocardicin E and S-adenosylmethionine". J. Am. Chem. Soc. 110 (24): 8238–8239. doi:10.1021/ja00232a047.
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