Inositol 3-kinase
In enzymology, an inositol 3-kinase (EC 2.7.1.64) is an enzyme that catalyzes the chemical reaction
- ATP + myo-inositol ADP + 1D-myo-inositol 3-phosphate
| inositol 3-kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.64 | ||||||||
| CAS no. | 37278-07-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are ATP and myo-inositol, whereas its two products are ADP and 1D-myo-inositol 3-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:myo-inositol 1-phosphotransferase. Other names in common use include inositol-1-kinase (phosphorylating), myoinositol kinase, and myo-inositol 1-kinase. This enzyme participates in inositol phosphate metabolism.
References
- English PD, Dietz M, Albersheim P (1966). "Myoinositol kinase: partial purification and identification of product". Science. 151 (3707): 198–199. doi:10.1126/science.151.3707.198.
- and Loewus FA; Sasaki, K.; Leavitt, A. L.; Munsell, L.; Sherman, W. R.; Loewus, F. A. (1982). "Enantiomeric form of myo-inositol-1-phosphate produced by myo-inositol-1-phosphate synthase and myoinositol kinase in higher-plants". Plant Physiol. 70 (6): 1661–1663. doi:10.1104/pp.70.6.1661. PMC 1065950. PMID 16662739.
- Stephens LR, Kay RR, Irvine RF (1990). "A myo-inositol D-3 hydroxykinase activity in Dictyostelium". Biochem. J. 272 (1): 201–10. PMC 1149677. PMID 2176081.
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