Inositol-hexakisphosphate kinase
Inositol-hexakisphosphate kinase (EC 2.7.4.21, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase) is an enzyme with systematic name ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- (1) ATP + 1D-myo-inositol hexakisphosphate(Phytic acid) ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
- (2) ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown)
| Inositol-hexakisphosphate kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.4.21 | ||||||||
| CAS no. | 176898-37-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Three mammalian isoforms are known to exist.
References
- Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH (November 1999). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Current Biology. 9 (22): 1323–6. doi:10.1016/S0960-9822(00)80055-X. PMID 10574768.
- Schell MJ, Letcher AJ, Brearley CA, Biber J, Murer H, Irvine RF (November 1999). "PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase". FEBS Letters. 461 (3): 169–72. doi:10.1016/S0014-5793(99)01462-3. PMID 10567691.
- Albert C, Safrany ST, Bembenek ME, Reddy KM, Reddy K, Falck J, Bröcker M, Shears SB, Mayr GW (October 1997). "Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells". The Biochemical Journal. 327 ( Pt 2) (2): 553–60. doi:10.1042/bj3270553. PMC 1218829. PMID 9359429.
External links
- Inositol-hexakisphosphate+kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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