Inositol-1,4-bisphosphate 1-phosphatase
The enzyme inositol-1,4-bisphosphate 1-phosphatase (EC 3.1.3.57) catalyzes the reaction
- 1D-myo-inositol 1,4-bisphosphate + H2O 1D-myo-inositol 4-phosphate + phosphate
| inositol-1,4-bisphosphate 1-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.3.57 | ||||||||
| CAS no. | 111070-17-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase. This enzyme is also called inositol-polyphosphate 1-phosphatase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1INP and 1JP4.
References
- Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF (1983). "Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides". Biochem. J. 212 (2): 473–82. doi:10.1042/bj2120473. PMC 1152070. PMID 6309146.
- Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW (1987). "The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes". J. Biol. Chem. 262 (5): 2146–9. PMID 3029066.
- Inhorn RC, Majerus PW (1987). "Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+". J. Biol. Chem. 262 (33): 15946–52. PMID 2824473.
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