Indolizine

Indolizine is an heterocyclic compound with the formula C8H7N). It is an uncommon isomer of indole with the nitrogen located at a ring fusion position. The saturated analogs are indolizidine, which are found in a variety of alkaloids such as swainsonine.[3]

Indolizine
Names
Preferred IUPAC name
Indolizine[1]
Other names
Pyrrocoline; Indolizin; Pyrrolo[1,2-a]pyridine
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.219.195
UNII
  • InChI=1S/C8H7N/c1-2-6-9-7-3-5-8(9)4-1/h1-7H checkY
    Key: HOBCFUWDNJPFHB-UHFFFAOYSA-N checkY
  • InChI=1/C8H7N/c1-2-6-9-7-3-5-8(9)4-1/h1-7H
    Key: HOBCFUWDNJPFHB-UHFFFAOYAH
  • c1ccc2ccccn12
Properties
C8H7N
Molar mass 117.151 g·mol−1
Appearance White solid
Melting point 75 °C (167 °F; 348 K)
Boiling point 205 °C (401 °F; 478 K)
Basicity (pKb) 10.1 [2]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

References
  1. International Union of Pure and Applied Chemistry (2014). Nomenclature of Organic Chemistry: IUPAC Recommendations and Preferred Names 2013. The Royal Society of Chemistry. p. 213. doi:10.1039/9781849733069. ISBN 978-0-85404-182-4.
  2. Elattar, K.M.; Youssef, I.; Fadda, A.A. (4 May 2016). "Reactivity of indolizines in organic synthesis". Synthetic Communications Reviews. 46 (9): 719–744. doi:10.1080/00397911.2016.1166252. S2CID 100777050.
  3. Julio Alvarez-Builla; Juan Jose Vaquero; José Barluenga, eds. (2011). Modern Heterocyclic Chemistry. Wiley-VCH.


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