Imidazoleacetate—phosphoribosyldiphosphate ligase
In enzymology, an imidazoleacetate—phosphoribosyldiphosphate ligase (EC 6.3.4.8) is an enzyme that catalyzes a chemical reaction
- ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate ADP + phosphate + 1-(5-phosphoribosyl)imidazole-4-acetate + diphosphate
| Imidazoleacetate—phosphoribosyldiphosphate ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.3.4.8 | ||||||||
| CAS no. | 37318-65-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are ATP, imidazole-4-acetate, and 5-phosphoribosyl diphosphate, whereas its 4 products are ADP, phosphate, 1-(5-phosphoribosyl)imidazole-4-acetate, and diphosphate.
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming). This enzyme is also called 5-phosphoribosylimidazoleacetate synthetase. This enzyme participates in histidine metabolism.
References
- Crowley GM (August 1964). "The enzymatic synthesis of 5'-phosphoribosylimidazoleacetic acid". The Journal of Biological Chemistry. 239: 2593–601. PMID 14235540.
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