Intersectin 2

ITSN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J3T, 1UDL, 1UE9, 1UFF, 1UHF, 3GF9, 3JZY, 4IIO
Identifiers
Aliases	ITSN2, PRO2015, SH3D1B, SH3P18, SWA, SWAP, intersectin 2
External IDs	OMIM: 604464 MGI: 1338049 HomoloGene: 22627 GeneCards: ITSN2
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[1]
End	4,763,962 bp[1]
RNA expression pattern
	n/a
	Top expressed in
	secondary oocyte; ; iris; ; ciliary body; ; spleen; ; conjunctival fornix; ; retinal pigment epithelium; ; blood; ; Region I of hippocampus proper; ; hair follicle; ; cornea;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; metal ion binding;
Cellular component	cytoplasm; centrosome; extracellular exosome;
Biological process	positive regulation of dendrite extension; cell differentiation; regulation of Rho protein signal transduction; endocytosis; positive regulation of signal transduction; regulation of molecular function; viral process;
	Sources:Amigo / QuickGO
Orthologs
	50618
	20403
	ENSG00000198399
	ENSMUSG00000020640
	Q9NZM3
	Q9Z0R6
	NM_147152; NM_006277; NM_019595
	NM_001198968; NM_001198969; NM_011365
NP_006268; NP_062541; NP_671494; NP_001335110; NP_001335111;
	NP_001335112; NP_001335113; NP_001335114; NP_001335115
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Intersectin-2 is a protein that in humans is encoded by the ITSN2 gene.[4][5][6]

This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined.[6]

Interactions

ITSN2 has been shown to interact with Wiskott-Aldrich syndrome protein.[5]

References

GRCm38: Ensembl release 89: ENSMUSG00000020640 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Pucharcos C, Estivill X, de la Luna S (Aug 2000). "Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis". FEBS Lett. 478 (1–2): 43–51. doi:10.1016/S0014-5793(00)01793-2. PMID 10922467. S2CID 24683452.
McGavin MK, Badour K, Hardy LA, Kubiseski TJ, Zhang J, Siminovitch KA (Dec 2001). "The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis". J Exp Med. 194 (12): 1777–87. doi:10.1084/jem.194.12.1777. PMC 2193569. PMID 11748279.
"Entrez Gene: ITSN2 intersectin 2".

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Sparks AB, Hoffman NG, McConnell SJ, et al. (1998). "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins". Nat. Biotechnol. 14 (6): 741–4. doi:10.1038/nbt0696-741. PMID 9630982. S2CID 11166026.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
Pucharcos C, Casas C, Nadal M, et al. (2001). "The human intersectin genes and their spliced variants are differentially expressed". Biochim. Biophys. Acta. 1521 (1–3): 1–11. doi:10.1016/s0167-4781(01)00276-7. PMID 11690630.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chini CC, Chen J (2003). "Human claspin is required for replication checkpoint control". J. Biol. Chem. 278 (32): 30057–62. doi:10.1074/jbc.M301136200. PMID 12766152.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Nishimura T, Yamaguchi T, Tokunaga A, et al. (2006). "Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2". Mol. Biol. Cell. 17 (3): 1273–85. doi:10.1091/mbc.E05-07-0700. PMC 1382316. PMID 16394100.
Seifert M, Ampofo C, Mehraein Y, et al. (2007). "Expression analysis of human intersectin 2 gene (ITSN2) minor splice variants showing differential expression in normal human brain". Oncol. Rep. 17 (5): 1207–11. doi:10.3892/or.17.5.1207. PMID 17390067.
Lim CS, Seet BT, Ingham RJ, et al. (2007). "The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction". Biochemistry. 46 (35): 9874–85. doi:10.1021/bi700357s. PMID 17696407.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000020640 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10922467-4] Pucharcos C, Estivill X, de la Luna S (Aug 2000). "Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis". FEBS Lett. 478 (1–2): 43–51. doi:10.1016/S0014-5793(00)01793-2. PMID 10922467. S2CID 24683452.

[pmid11748279-5] McGavin MK, Badour K, Hardy LA, Kubiseski TJ, Zhang J, Siminovitch KA (Dec 2001). "The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis". J Exp Med. 194 (12): 1777–87. doi:10.1084/jem.194.12.1777. PMC 2193569. PMID 11748279.

[entrez-6] "Entrez Gene: ITSN2 intersectin 2".

Intersectin 2

Interactions

References

Further reading