IGHE
Ig epsilon chain C region is a protein that in humans is encoded by the IGHE gene.[3]
| IGHE | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | IGHE, IgE, immunoglobulin heavy constant epsilon | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 147180 GeneCards: IGHE | ||||||||||||||||||||||||||||||||||||||||||||||||||
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IGHE immunoglobulin heavy constant epsilon, (located on chromosome 14 for humans) has been predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Predicted to be located in extracellular region. Predicted to be part of immunoglobulin complex, circulating. Predicted to be active in external side of plasma membrane. [4]
- IGHE (immunoglobulin heavy constant epsilon): The gene that encodes the ε heavy chain constant region for the IgE antibody. This gene is critical for the production and function of IgE in the body. The IGHE gene provides instructions for making a part of an antibody (immunoglobulin) called Immunoglobulin E, or IgE.[5]
Immunoglobulin E (IgE) are antibodies produced by the immune system.
If you have an allergy, your immune system overreacts to an allergen by producing antibodies called Immunoglobulin E (IgE). These antibodies travel to cells that release chemicals, causing an allergic reaction. This reaction usually causes symptoms in the nose, lungs, throat, or on the skin.
Each type of IgE has specific "radar" for each type of allergen. That's why some people are only allergic to cat dander (they only have the IgE antibodies specific to cat dander); while others have allergic reactions to multiple allergens because they have many more types of IgE antibodies.[6]
References
- GRCh38: Ensembl release 89: ENSG00000211891 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: IGHE immunoglobulin heavy constant epsilon".
- "IGHE immunoglobulin heavy constant epsilon [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-10-17.
- "UniProt". www.uniprot.org. Retrieved 2023-10-17.
- "Immunoglobulin E (IgE) Defined". American Academy of Allergy Asthma and Immunology.
Further reading
- Venkitaraman AR, Williams GT, Dariavach P, Neuberger MS (Aug 1991). "The B-cell antigen receptor of the five immunoglobulin classes". Nature. 352 (6338): 777–81. Bibcode:1991Natur.352..777V. doi:10.1038/352777a0. PMID 1881434. S2CID 4246284.
- Padlan EA, Davies DR (Oct 1986). "A model of the Fc of immunoglobulin E". Molecular Immunology. 23 (10): 1063–75. doi:10.1016/0161-5890(86)90005-2. PMID 3796618.
- Flanagan JG, Rabbitts TH (1984). "The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes". The EMBO Journal. 1 (5): 655–60. doi:10.1002/j.1460-2075.1982.tb01223.x. PMC 553102. PMID 6234164.
- Max EE, Battey J, Ney R, Kirsch IR, Leder P (Jun 1982). "Duplication and deletion in the human immunoglobulin epsilon genes". Cell. 29 (2): 691–9. doi:10.1016/0092-8674(82)90185-4. PMID 6288268. S2CID 54345379.
- Ellison J, Buxbaum J, Hood L (1983). "Nucleotide sequence of a human immunoglobulin C gamma 4 gene". DNA. 1 (1): 11–8. doi:10.1089/dna.1.1981.1.11. PMID 6299662.
- Seno M, Kurokawa T, Ono Y, Onda H, Sasada R, Igarashi K, Kikuchi M, Sugino Y, Nishida Y, Honjo T (Feb 1983). "Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA". Nucleic Acids Research. 11 (3): 719–26. doi:10.1093/nar/11.3.719. PMC 325748. PMID 6300763.
- Ueda S, Nakai S, Nishida Y, Hisajima H, Honjo T (1984). "Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns". The EMBO Journal. 1 (12): 1539–44. doi:10.1002/j.1460-2075.1982.tb01352.x. PMC 553248. PMID 6327276.
- Hisajima H, Nishida Y, Nakai S, Takahashi N, Ueda S, Honjo T (May 1983). "Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin". Proceedings of the National Academy of Sciences of the United States of America. 80 (10): 2995–9. doi:10.1073/pnas.80.10.2995. PMC 393960. PMID 6407005.
- Flanagan JG, Lefranc MP, Rabbitts TH (Mar 1984). "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences". Cell. 36 (3): 681–8. doi:10.1016/0092-8674(84)90348-9. PMID 6421489. S2CID 54312675.
- Ellison J, Hood L (Mar 1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 79 (6): 1984–8. Bibcode:1982PNAS...79.1984E. doi:10.1073/pnas.79.6.1984. PMC 346106. PMID 6804948.
- Kenten JH, Molgaard HV, Houghton M, Derbyshire RB, Viney J, Bell LO, Gould HJ (Nov 1982). "Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line". Proceedings of the National Academy of Sciences of the United States of America. 79 (21): 6661–5. doi:10.1073/pnas.79.21.6661. PMC 347188. PMID 6815656.
- Valenta R, Natter S, Seiberler S, Wichlas S, Maurer D, Hess M, Pavelka M, Grote M, Ferreira F, Szepfalusi Z, Valent P, Stingl G (Dec 1998). "Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients". The Journal of Investigative Dermatology. 111 (6): 1178–83. doi:10.1046/j.1523-1747.1998.00413.x. PMID 9856836.
- Anderson GG, Leaves NI, Bhattacharyya S, Zhang Y, Walshe V, Broxholme J, Abecasis G, Levy E, Zimmer M, Cox R, Cookson WO (Apr 2002). "Positive association to IgE levels and a physical map of the 13q14 atopy locus". European Journal of Human Genetics. 10 (4): 266–70. doi:10.1038/sj.ejhg.5200801. PMID 12032735.
- Cocco RR, Järvinen KM, Sampson HA, Beyer K (Aug 2003). "Mutational analysis of major, sequential IgE-binding epitopes in alpha s1-casein, a major cow's milk allergen". The Journal of Allergy and Clinical Immunology. 112 (2): 433–7. doi:10.1067/mai.2003.1617. PMID 12897753.
- Hajoui O, Janani R, Tulic M, Joubert P, Ronis T, Hamid Q, Zheng H, Mazer BD (Sep 2004). "Synthesis of IL-13 by human B lymphocytes: regulation and role in IgE production". The Journal of Allergy and Clinical Immunology. 114 (3): 657–63. doi:10.1016/j.jaci.2004.05.034. PMID 15356573.
- Takhar P, Smurthwaite L, Coker HA, Fear DJ, Banfield GK, Carr VA, Durham SR, Gould HJ (Apr 2005). "Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis". Journal of Immunology. 174 (8): 5024–32. doi:10.4049/jimmunol.174.8.5024. PMID 15814733.
- Batra J, Rajpoot R, Ahluwalia J, Devarapu SK, Sharma SK, Dinda AK, Ghosh B (Jun 2007). "A hexanucleotide repeat upstream of eotaxin gene promoter is associated with asthma, serum total IgE and plasma eotaxin levels". Journal of Medical Genetics. 44 (6): 397–403. doi:10.1136/jmg.2006.046607. PMC 2740889. PMID 17220216.
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