IFT74

IFT74
Identifiers
Aliases	IFT74, CCDC2, CMG-1, CMG1, intraflagellar transport 74, BBS20, BBS22, SPGF58, JBTS40
External IDs	OMIM: 608040 MGI: 1914944 HomoloGene: 11831 GeneCards: IFT74
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	27,066,134 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	94,693,229 bp[2]
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; caput epididymis; ; right uterine tube; ; Achilles tendon; ; corpus epididymis; ; sperm; ; rectum; ; left lobe of thyroid gland; ; anterior pituitary; ; left adrenal gland;
	Top expressed in
	seminiferous tubule; ; olfactory epithelium; ; spermatid; ; spermatocyte; ; maxillary prominence; ; saccule; ; otic placode; ; pineal gland; ; vas deferens; ; mirror;
	More reference expression data
	n/a
Gene ontology
Molecular function	chromatin binding; beta-tubulin binding; protein binding;
Cellular component	intraciliary transport particle B; centrosome; cell projection; ciliary tip; motile cilium; cytoplasmic vesicle; nucleus; cilium;
Biological process	Notch signaling pathway; intraciliary transport; heart development; keratinocyte development; determination of left/right symmetry; cell projection organization; epidermis development; negative regulation of epithelial cell proliferation; positive regulation of cell adhesion mediated by integrin; positive regulation of transcription by RNA polymerase II; intraciliary transport involved in cilium assembly; cilium assembly; non-motile cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
	80173
	67694
	ENSG00000096872
	ENSMUSG00000028576
	Q96LB3
	Q8BKE9
	NM_001099222; NM_001099223; NM_001099224; NM_025103; NM_001349928
	NM_001290568; NM_026319
	NP_001092692; NP_001092693; NP_001092694; NP_079379; NP_001336857
	NP_001277497; NP_080595
	Wikidata
View/Edit Human	View/Edit Mouse

Intraflagellar transport protein 74 homolog (IFT74), also known as coiled-coil domain-containing protein 2 (CCDC2) and capillary morphogenesis gene 1 protein (CMG1), is a protein that in humans is encoded by the IFT74 gene.[5][6]

BCMG1 is upregulated by umbilical vein endothelial cells during capillary morphogenesis.[6]

References

GRCh38: Ensembl release 89: ENSG00000096872 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028576 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: intraflagellar transport 74 homolog (Chlamydomonas)".
Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA, Davis GE (August 2001). "Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling". J. Cell Sci. 114 (Pt 15): 2755–73. doi:10.1242/jcs.114.15.2755. PMID 11683410.

Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Xiao S, Sato C, Kawarai T, et al. (2008). "Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis". Neurobiol. Aging. 29 (8): 1279–82. doi:10.1016/j.neurobiolaging.2007.02.022. PMID 17383054. S2CID 10392826.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000096872 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028576 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: intraflagellar transport 74 homolog (Chlamydomonas)".

[pmid11683410-6] Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA, Davis GE (August 2001). "Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling". J. Cell Sci. 114 (Pt 15): 2755–73. doi:10.1242/jcs.114.15.2755. PMID 11683410.

IFT74

References

Further reading