Interstate 29 in North Dakota

I-29 northbound just north of South Dakota border

I-29 enters North Dakota, with a speed limit of 75 mph (121 km/h), from South Dakota to the south, traveling in a north-northeasterly direction at an approximate elevation of 1,100 feet (340 m) above sea level. The first exit in the state, exit 1, is to a county road built along the state line. This exit serves the Dakota Magic Casino and Hotel. Rural exits are somewhat common in North Dakota. There are exits with no major communities near them about every eight miles (13 km) from the South Dakota state linee to Fargo. There is also one exit serving North Dakota Highway 11 (ND 11) to Hankinson and one exit serving ND 13 to Wahpeton.

I-29 at exit 65 in Fargo

I-29 has a speed limit of 65 mph (105 km/h) between exits 60 and 62, and a speed limit of 55 mph (89 km/h) for the next six exits in Fargo, including interchanges with I-94 and US 10. There is also an exit that serves Hector International Airport. Farther north, there is an exit that indirectly serves Fargo via County Road 22 (CR 22) that mainly serves Harwood.

North of Fargo, with a speed limit of 75 mph (121 km/h), there are exits roughly every six miles (9.7 km) until the route enters Hillsboro. I-29 has one exit south of the city serving its municipal airport and one exit serving the city itself. About six miles (9.7 km) north of Hillsboro, the highway shares an interchange with ND 200, a major thoroughfare across central North Dakota. There are three more exits between Hillsboro and Grand Forks, including one serving Thompson, the southernmost suburb of Grand Forks.

The highway has a speed limit of 75 mph (121 km/h), and just four exits serving Grand Forks. One of them serves US 2, which leads to Grand Forks International Airport.

With a speed limit of 75 mph (121 km/h), 10 miles (16 km) north of the city, I-29's first concurrency with US 81 ends in Manvel. The highway's next exit is 10 miles (16 km) north of Manvel at an interchange with ND 54, which indirectly serves Oslo, Minnesota, about three miles (4.8 km) east of the Interstate. There are a couple more minor exits between the Oslo exit and Drayton. The highway has two exits in Drayton, one with ND 44 and one with ND 66.

After several more exits in the open country serving minor county highways, I-29 begins another concurrency with US 81 at an exit with ND 5. After one more exit serving a county road, the highways enter Pembina. In Pembina, I-29 has its final exit in the United States at an interchange with ND 59 and CR 55. Three miles (4.8 km) north of Pembina, I-29/US 81 enters Manitoba, Canada, and becomes Provincial Trunk Highway 75 (PTH 75), which leads north to Winnipeg. The highway crosses the international border at an approximate elevation of 800 feet (245 m) above sea level.