Hydroxypyruvate reductase
In enzymology, a hydroxypyruvate reductase (EC 1.1.1.81) is an enzyme that catalyzes the chemical reaction
- D-glycerate + NAD(P)+ hydroxypyruvate + NAD(P)H + H+
| hydroxypyruvate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.81 | ||||||||
| CAS no. | 9059-44-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are D-glycerate, NAD+, and NADP+, whereas its 4 products are hydroxypyruvate, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glycerate:NADP+ 2-oxidoreductase. Other names in common use include beta-hydroxypyruvate reductase, NADH:hydroxypyruvate reductase, and D-glycerate dehydrogenase. This enzyme participates in glycine, serine and threonine metabolism and glyoxylate and dicarboxylate metabolism.
See also
- Oxidoreductases
- Enzymes
- Enzyme Commission number (EC number)
References
- Kleczkowski LA; Edwards GE (1989). "Identification of hydroxypyruvate and glyoxylate reductases in maize leaves". Plant Physiol. 91 (1): 278–286. doi:10.1104/pp.91.1.278. PMC 1061987. PMID 16667010.
- Kleczkowski LA, Randall DD (1988). "Purification and characterization of a novel NADPH(NADH)-dependent hydroxypyruvate reductase from spinach leaves. Comparison of immunological properties of leaf hydroxypyruvate reductases". Biochem. J. 250 (1): 145–52. doi:10.1042/bj2500145. PMC 1148826. PMID 3281657.
- Kohn LD, Jakoby WB (1968). "Tartaric acid metabolism. VII. Crystalline hydroxypyruvate reductase (D-glycerate dehydrogenase)". J. Biol. Chem. 243 (10): 2494–9. PMID 4385077.
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