Hunchback (gene)
Hunchback is a maternal effect gene and gap gene found in the egg and zygotic genome of Drosophila embryogenesis. It is activated by the maternal Bicoid morphogen gradient and determines the anterior-posterior axis within the syncytial blastoderm.[1] Hunchback is a Zinc finger transcription factor that coordinates the expression of other gap genes such as Krüppel, knirps, and giant.[2]
| Hunchback (gene) | |||||||
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| UniProt | P05084 | ||||||
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Hunchback protein is expressed in the neuroblasts of many insects, not just Drosophila. Maternal hunchback gene expression is not only found in insects, but also annelids and nematodes.[3]
References
- Desponds, J; Vergassola, M; Walczak, AM (29 July 2020). "A mechanism for hunchback promoters to readout morphogenetic positional information in less than a minute". eLife. 9. doi:10.7554/eLife.49758. PMC 7428309. PMID 32723476.
- Perry, Michael W.; Bothma, Jacques P.; Luu, Ryan D.; Levine, Michael (2012). "Precision of Hunchback Expression in the Drosophila Embryo". Current Biology. Elsevier BV. 22 (23): 2247–2252. doi:10.1016/j.cub.2012.09.051. ISSN 0960-9822. PMC 4257490. PMID 23122844.
- Pinnell, Jamie; Lindeman, Paul S.; Colavito, Sierra; Lowe, Chris; Savage, Robert M. (2006). "The Divergent Roles of the Segmentation Gene hunchback". Integrative and Comparative Biology. 46 (4): 519–532. doi:10.1093/icb/icj054. ISSN 1540-7063. JSTOR 3884812. PMID 21672763. Retrieved 5 February 2023.
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