Human Cell Atlas

The Human Cell Atlas is a project to describe all cell types in the human body. The initiative was announced by a consortium after its inaugural meeting in London in October 2016, which established the first phase of the project.[1][2] Aviv Regev and Sarah Teichmann defined the goals of the project at that meeting,[3] which was convened by the Broad Institute, the Wellcome Trust Sanger Institute and Wellcome Trust.[4] Regev and Teichmann lead the project.[5]

Human Cell Atlas
Content
OrganismsHuman
Access
Websitewww.humancellatlas.org

Description

The Human Cell Atlas will catalogue a cell based on several criteria, specifically the cell type, its state, its location in the body, the transitions it undergoes, and its lineage.[6] It will gather data from existing research, and integrate it with data collected in future research projects.[2] Among the data it will collect is the fluxome, genome, metabolome, proteome, and transcriptome.[2]

Its scope is to categorize the 37 trillion cells of the human body to determine which genes each cell expresses by sampling cells from all parts of the body.[7]

All aspects of the project will be made "available to the public for free", including software and results.[8]

By April 2018, the project included more than 480 researchers conducting 185 projects.[9]

Funding

In October 2017, the Chan Zuckerberg Initiative announced funding for 38 projects related to the Human Cell Atlas.[10] Among them was a grant of undisclosed value to the Zuckerman Institute of the Columbia University Medical Center at Columbia University.[8] The grant, titled "A strategy for mapping the human spinal cord with single cell resolution", will fund research to identify and catalogue gene activity in all spinal cord cells.[8] The Translational Genomics Research Institute received a grant to develop a standard for the "processing and storage of solid tissues for single-cell RNA sequencing", compared to the typical practice of relying on the average of sequencing multiple cells.[10] Project home pages are available at the Chan Zuckerberg Initiative's website.[11]

The program is also backed by European Union, the National Institutes of Health in the United States, and the Manton Foundation.[7]

Data

In April 2018, the first data set from the project was released, representing 530,000 immune system cells collected from bone marrow and cord blood.[9]

A research program at the Max Planck Institute of Immunobiology and Epigenetics published an atlas of the cells of the liver, using single-cell RNA sequencing on 10,000 normal cells obtained from nine donors.[12]

The Tabula Sapeins data was published on a dedicated website[13]

See also

Notes
  1. Preidt 2016.
  2. Yup 2017.
  3. Sample 2016.
  4. Wellcome Trust Sanger Institute 2016.
  5. Nowogrodzki 2017.
  6. Regev, p. 4.
  7. Apple 2018.
  8. Silva 2017.
  9. Daley 2018.
  10. AZ Big Media 2017.
  11. from https://www.czbiohub.org/tabula-projects/
  12. Aizarani et al. 2019.
  13. Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, et al. (Tabula Sapiens Consortium) (May 2022). "The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans". Science. 376 (6594): eabl4896. doi:10.1126/science.abl4896. PMC 9812260. PMID 35549404. S2CID 248748505.

References

Further reading
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.