HERC5

HERC5
Identifiers
Aliases	HERC5, CEB1, CEBP1, HECT and RLD domain containing E3 ubiquitin protein ligase 5
External IDs	OMIM: 608242 HomoloGene: 81848 GeneCards: HERC5
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	88,506,163 bp[1]
RNA expression pattern
	Top expressed in
	sperm; ; germinal epithelium; ; monocyte; ; palpebral conjunctiva; ; blood; ; Achilles tendon; ; islet of Langerhans; ; bone marrow; ; myometrium; ; ascending aorta;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ISG15 transferase activity; protein binding; transferase activity; RNA binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity;
Cellular component	perinuclear region of cytoplasm; cytosol; cytoplasm;
Biological process	ISG15-protein conjugation; negative regulation of type I interferon production; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of defense response to virus; defense response to virus; immune system process; protein polyubiquitination; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	51191
	n/a
	ENSG00000138646
	n/a
	Q9UII4
	n/a
	NM_016323
	n/a
	NP_057407
	n/a
	Wikidata
View/Edit Human

Probable E3 ubiquitin-protein ligase HERC5 is an enzyme that in humans is encoded by the HERC5 gene.[3][4]

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.[4] HERC5 has been shown to exhibit antiviral activity towards HIV-1, influenza A virus and human papillomavirus.[5][6][7]

Interactions

HERC5 has been shown to interact with NME2[8] and Cyclin E1.[3]

References

GRCh38: Ensembl release 89: ENSG00000138646 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M (Jan 2000). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins". Biochem Biophys Res Commun. 266 (1): 115–22. doi:10.1006/bbrc.1999.1777. PMID 10581175.
"Entrez Gene: HERC5 hect domain and RLD 5".
Woods MW, Kelly JN, Hattlmann CJ, Tong JG, Xu LS, Coleman MD, Quest GR, Smiley JR, Barr SD (Nov 2011). "Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag". Retrovirology. 8: 95. doi:10.1186/1742-4690-8-95. PMC 3228677. PMID 22093708.
Tang Y, Zhong G, Zhu L, Liu X, Shan Y, Feng H, Bu Z, Chen H, Wang C (May 2010). "Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein". J Immunol. 184 (10): 5777–90. doi:10.4049/jimmunol.0903588. PMID 20385878.
Durfee LA, Lyon N, Seo K, Huibregtse JM (June 2010). "The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15". Mol Cell. 38 (5): 722–32. doi:10.1016/j.molcel.2010.05.002. PMC 2887317. PMID 20542004.
Hochrainer, K; Kroismayr R; Baranyi U; Binder B R; Lipp J (Jul 2008). "Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B". Cell. Mol. Life Sci. Switzerland. 65 (13): 2105–17. doi:10.1007/s00018-008-8148-5. ISSN 1420-682X. PMID 18535780. S2CID 6897759.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138646 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10581175-3] Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M (Jan 2000). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins". Biochem Biophys Res Commun. 266 (1): 115–22. doi:10.1006/bbrc.1999.1777. PMID 10581175.

[entrez-4] "Entrez Gene: HERC5 hect domain and RLD 5".

[pmid22093708-5] Woods MW, Kelly JN, Hattlmann CJ, Tong JG, Xu LS, Coleman MD, Quest GR, Smiley JR, Barr SD (Nov 2011). "Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag". Retrovirology. 8: 95. doi:10.1186/1742-4690-8-95. PMC 3228677. PMID 22093708.

[pmid_20385878-6] Tang Y, Zhong G, Zhu L, Liu X, Shan Y, Feng H, Bu Z, Chen H, Wang C (May 2010). "Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein". J Immunol. 184 (10): 5777–90. doi:10.4049/jimmunol.0903588. PMID 20385878.

[pmid_20542004-7] Durfee LA, Lyon N, Seo K, Huibregtse JM (June 2010). "The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15". Mol Cell. 38 (5): 722–32. doi:10.1016/j.molcel.2010.05.002. PMC 2887317. PMID 20542004.

[pmid18535780-8] Hochrainer, K; Kroismayr R; Baranyi U; Binder B R; Lipp J (Jul 2008). "Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B". Cell. Mol. Life Sci. Switzerland. 65 (13): 2105–17. doi:10.1007/s00018-008-8148-5. ISSN 1420-682X. PMID 18535780. S2CID 6897759.