Gordon MacPherson

Dr George Gordon MacPherson was Reader in Experimental Pathology, Turnbull Fellow, Tutor in Medicine, and Senior Tutor at Oriel College, Oxford. He held a Bachelor's degree (B.M.), Master's degree (M.A.) and a doctorate (D.Phil.). His research interests were in Cell Biology, Pathology, and Immunology. Medically qualified, he researched in the field of cellular immunology at the Sir William Dunn School of Pathology, University of Oxford.

He is recognized for his "pioneering work"[1] on the modulation of the adaptive immune response by sub-populations of antigen-presenting dendritic cells, including a sub-population of dendritic cells which presents self-antigens derived from apoptotic gastrointestinal epithelial cells and helps maintain self-tolerance.[2] This contrasts with the role of other dendritic cells in presenting pathogen-derived antigens in order to activate specific anti-pathogen T-cell and B-cell responses.

He died on 14 November 2021.

Publications

As at December 2021, his ten most cited research publications are:

References
  1. Iwasaki, Akiko (1 April 2007). "Mucosal Dendritic Cells". Annual Review of Immunology. 25 (1): 381–418. doi:10.1146/annurev.immunol.25.022106.141634. PMID 17378762.
  2. Huang, Fang-Ping; Platt, Nicholas; Wykes, Michelle; Major, James R.; Powell, Timothy J.; Jenkins, Christopher D.; MacPherson, G. Gordon (7 February 2000). "A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes". Journal of Experimental Medicine. 191 (3): 435–444. doi:10.1084/jem.191.3.435. PMC 2195813. PMID 10662789.
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