Auxiliary Activity family 9

Auxiliary Activity family 9 (formerly GH61) is a family of lytic polysaccharide monooxygenases. The family was previously incorrectly classified as glycoside hydrolase family 61, however it was re-classified in March 2013.[1][2]

Auxiliary Activity Family 9
Identifiers
SymbolAux_Act_9
PfamPF03443
InterProIPR005103
CAZyAA9
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

AA9 is known to be a copper dependent, oxidative enzyme able to cleave crystalline cellulose.[3] Activity greatly depends on the presence of a divalent copper ion and a reductant such as gallate or ascorbate. The oxidative action of AA9 can work on either the reducing or the non-reducing end of glucose moieties. Although AA9 enzymes can be found in a large spectrum of biomass degrading fungi, research into this family is relatively new.[4] This classification is available on the CAZy web site,[5][6] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[7][8][9]

References
  1. Levasseur, Anthony; Drula, Elodie; Lombard, Vincent; Coutinho, Pedro M.; Henrissat, Bernard (2013-03-21). "Expansion of the enzymatic repertoire of the CAZy database to integrate auxiliary redox enzymes". Biotechnology for Biofuels. 6 (1): 41. doi:10.1186/1754-6834-6-41. ISSN 1754-6834. PMC 3620520. PMID 23514094.
  2. Hemsworth, Glyn R; Davies, Gideon J; Walton, Paul H (2013). "Recent insights into copper-containing lytic polysaccharide mono-oxygenases". Current Opinion in Structural Biology. 23 (5): 660–668. doi:10.1016/j.sbi.2013.05.006. PMID 23769965.
  3. Vaaje-Kolstad, Gustav; Westereng, Bjørge; Horn, Svein J.; Liu, Zhanliang; Zhai, Hong; Sørlie, Morten; Eijsink, Vincent G. H. (2010-10-08). "An Oxidative Enzyme Boosting the Enzymatic Conversion of Recalcitrant Polysaccharides". Science. 330 (6001): 219–222. Bibcode:2010Sci...330..219V. doi:10.1126/science.1192231. ISSN 0036-8075. PMID 20929773. S2CID 206527624.
  4. Bey, Mathieu; Zhou, Simeng; Poidevin, Laetitia; Henrissat, Bernard; Coutinho, Pedro M.; Berrin, Jean-Guy; Sigoillot, Jean-Claude (2013-01-15). "Cello-Oligosaccharide Oxidation Reveals Differences between Two Lytic Polysaccharide Monooxygenases (Family GH61) from Podospora anserina". Applied and Environmental Microbiology. 79 (2): 488–496. doi:10.1128/aem.02942-12. ISSN 0099-2240. PMC 3553762. PMID 23124232.
  5. "Home". CAZy.org. Retrieved 2018-03-06.
  6. Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B (January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research. 42 (Database issue): D490–5. doi:10.1093/nar/gkt1178. PMC 3965031. PMID 24270786.
  7. "Auxiliary Activity Family 9". CAZypedia.org. Retrieved 2018-03-08.
  8. "Glycoside Hydrolase Family 61". CAZypedia.org. Retrieved 2018-03-06.
  9. CAZypedia Consortium (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes" (PDF). Glycobiology. 28 (1): 3–8. doi:10.1093/glycob/cwx089. PMID 29040563.
This article incorporates text from the public domain Pfam and InterPro: IPR005103
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