Glycerophospholipid arachidonoyl-transferase (CoA-independent)

In the field of enzymology, a glycerophospholipid arachidonoyl-transferase (CoA-independent) (EC 2.3.1.147) is an enzyme that catalyzes the chemical reaction:

1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine 1-organyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + 1-organyl-2-lyso-sn-glycero-3-phosphocholine
glycerophospholipid arachidonoyl-transferase (CoA-independent)
Identifiers
EC no.2.3.1.147
CAS no.102347-79-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme catalyzes the transfer of arachidonic acid and other polyenoic fatty acids from intact choline or ethanolamine-containing glycerophospholipids to the sn-2 position of a lyso- glycerophospholipid. The organyl group on sn-1 of the donor or acceptor molecule can be alkyl, acyl or alk-1-enyl. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups.

Nomenclature

The systematic name of this enzyme class is 1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lys o-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent).

References
    • Robinson M, Blank ML, Snyder F (1985). "Acylation of lysophospholipids by rabbit alveolar macrophages Specificities of CoA-dependent and CoA-independent reactions". J. Biol. Chem. 260 (13): 7889–95. PMID 4008481.
    • Snyder F, Lee TC, Blank ML (1992). "The role of transacylases in the metabolism of arachidonate and platelet activating factor". Prog. Lipid Res. 31 (1): 65–86. doi:10.1016/0163-7827(92)90016-C. PMID 1641397.


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