Glycerol-3-phosphate cytidylyltransferase
In enzymology, a glycerol-3-phosphate cytidylyltransferase (EC 2.7.7.39) is an enzyme that catalyzes the chemical reaction
- CTP + sn-glycerol 3-phosphate diphosphate + CDP-glycerol
| glycerol-3-phosphate cytidylyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.7.39 | ||||||||
| CAS no. | 9027-11-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are CTP and sn-glycerol 3-phosphate, whereas its two products are diphosphate and CDP-glycerol.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:sn-glycerol-3-phosphate cytidylyltransferase. Other names in common use include CDP-glycerol pyrophosphorylase, cytidine diphosphoglycerol pyrophosphorylase, cytidine diphosphate glycerol pyrophosphorylase, CTP:glycerol 3-phosphate cytidylyltransferase, and Gro-PCT. This enzyme participates in glycerophospholipid metabolism.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1COZ, 1N1D, and 2B7L.
References
- Shaw DR (February 1962). "Pyrophosphorolysis and enzymic synthesis of cytidine diphosphate glycerol and cytidine diphosphate ribitol". The Biochemical Journal. 82 (2): 297–312. doi:10.1042/bj0820297. PMC 1243453. PMID 13911452.