Glutamate—ethylamine ligase
In enzymology, a glutamate—ethylamine ligase (EC 6.3.1.6) is an enzyme that catalyzes the chemical reaction
- ATP + L-glutamate + ethylamine ADP + phosphate + N5-ethyl-L-glutamine
| Glutamate—ethylamine ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.3.1.6 | ||||||||
| CAS no. | 62213-31-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are ATP, L-glutamate, and ethylamine, whereas its 3 products are ADP, phosphate, and N5-ethyl-L-glutamine.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is L-glutamate:ethylamine ligase (ADP-forming). Other names in common use include N5-ethyl-L-glutamine synthetase, theanine synthetase, and N5-ethylglutamine synthetase.
References
- Sasaoka K; Kito M (1964). "Synthesis of theanine by tea seedling homogenate". Agric. Biol. Chem. 28 (5): 313–317. doi:10.1271/bbb1961.28.313.
- Sasaoka K, Kito M, Inagaki H (1963). "Studies on the biosynthesis of theanine in tea seedlings. Synthesis of theanine by the homogenate of tea seedlings". Agric. Biol. Chem. 27: 467–468. doi:10.1271/bbb1961.27.467.
- Sasaoka K, Kito M, Onishi Y (1965). "Some properties of the theanine synthesizing enzyme in tea seedlings". Agric. Biol. Chem. 29 (11): 984–988. doi:10.1271/bbb1961.29.984.
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