Global Alliance for Genomics and Health

The Global Alliance for Genomics and Health (GA4GH) is an international consortium that is developing standards for responsibly collecting, storing, analyzing, and sharing genomic data in order to enable an "internet of genomics".[1][2] GA4GH was founded in 2013.[3]

GA4GH is founded on the Framework for the Responsible Sharing of Genomic and Health-related Data,[4] which is based on the human right to benefit from scientific advances.[5]

Organization

GA4GH maintained by four Host Institutions (Wellcome Sanger Institute, Broad Institute, Ontario Institute for Cancer Research and the European Bioinformatics Institute).[6] Ewan Birney is the current GA4GH chair[7] and Peter Goodhand is the Chief Executive Officer.[8] Heidi Rehm and Kathryn North are the current Vice Chairs.[9]

Organizational members of the alliance include:[6]

Funding

GA4GH is supported by a "Funder's Forum" composed of organizations whose funding commitments exceed USD $200,000 annually, for at least three years. Forum members include:[6]

Activities

All GA4GH standards are developed by six technical and two foundational "Work Streams" in collaboration with real-world genomic data initiatives called "Driver Projects."[8]

GA4GH Work Streams
  1. Regulatory and Ethics (foundational)[7]  
  2. Data Security (foundational)[7]  
  3. Cloud[7]  
  4. Clinical & Phenotypic Data Capture [7]  
  5. Data Use and Researcher Identities[7]  
  6. Discovery[7]  
  7. Genomic Knowledge Standards[7]  
  8. Large Scale Genomics[7]  

GA4GH Driver Projects
  1. All of US Research Program[3]
  2. Australian Genomics[3]
  3. BRCA Challenge[3]
  4. Canadian Distributed Infrastructure for Genomics (CanDig)[3]
  5. Clinical Genome Resource (ClinGen)[3]
  6. ELIXIR Beacon[3]
  7. The European Nucleotide Archive, European Variation Archive, and European Genome-phenome Archive at EMBL-EBI[3]
  8. EUCANCan [10]
  9. European Joint Programme on Rare Diseases [11]
  10. Genomics England[12]
  11. Human Cell Atlas[12]
  12. Human Heredity and Health in Africa (H3Africa) [13]
  13. International Cancer Genome Consortium - ARGO[12]
  14. Matchmaker Exchange[12]
  15. The Monarch Initiative[12]
  16. National Cancer Institute Data Commons Framework (NCI DCF) and Genomic Data Commons (NCI GDC)[12]
  17. Trans-Omics for Precision Medicine (TOPMed)[12]
  18. Variant Interpretation for Cancer Consortium (VICC)[12]

References
  1. Regalado, Antonio. "Networks of Genome Data Will Transform Medicine". MIT Technology Review. Retrieved 2018-10-23.
  2. Salisbury, Meredith. "The IoT Of Health: Big Data Can Make Us Healthier". Forbes. Retrieved 2018-10-23.
  3. Petrone, Justin (October 17, 2017). "Global Alliance for Genomics and Health Releases Strategic Plan, Announces Driver Projects". GenomeWeb. Retrieved 2018-10-24.
  4. Scialom, Mike. "A RAREfest insight into genetic medicine". Cambridge Independent. Retrieved 2018-10-23.
  5. "Article 27". www.claiminghumanrights.org (in German). Retrieved 2018-10-23.
  6. "Funders and sponsors". GA4GH. Archived from the original on 2022-02-09. Retrieved 2022-11-20.
  7. Raths, David (February 7, 2018). "Global Alliance for Genomics and Health Launches Ambitious Roadmap". Healthcare Informatics Magazine. Retrieved 2018-10-23.
  8. Ross, Benjamin (February 26, 2018). "GA4GH Releases 2018 Strategic Roadmap". www.bio-itworld.com. Retrieved 2018-10-24.
  9. "Bio-IT World". www.bio-itworld.com. Retrieved 2019-01-16.
  10. "EUCANCan". eucancan.com. Retrieved 2022-03-24.
  11. "European Joint Programme on Rare Diseases". www.ejprarediseases.org. Retrieved 2022-03-24.
  12. Proffitt, Allison (October 17, 2017). "GA4GH Announces New Strategic Plan, Vision To Create Standards". www.bio-itworld.com. Retrieved 2018-10-24.
  13. "H3Africa". h3africa.org. Retrieved 2022-03-24.
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