Gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase
γ-L-Glutamyl-butirosin B γ-glutamyl cyclotransferase (EC 4.3.2.6, btrG (gene)) is an enzyme with systematic name γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase (5-oxo-L-proline producing).[1] This enzyme catalyses the following chemical reaction
- γ-L-glutamyl-butirosin B butirosin B + 5-oxo-L-proline
| γ-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.3.2.6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B.
References
- Llewellyn NM, Li Y, Spencer JB (April 2007). "Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain". Chemistry & Biology. 14 (4): 379–86. doi:10.1016/j.chembiol.2007.02.005. PMID 17462573.
External links
- Gamma-L-glutamyl-butirosin+B+gamma-glutamyl+cyclotransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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