Galactosyldiacylglycerol alpha-2,3-sialyltransferase
In enzymology, a galactosyldiacylglycerol alpha-2,3-sialyltransferase (EC 2.4.99.5) is an enzyme that catalyzes the chemical reaction
- CMP-N-acetylneuraminate + 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol CMP + 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn- glycerol
| galactosyldiacylglycerol alpha-2,3-sialyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.99.5 | ||||||||
| CAS no. | 80237-98-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol, whereas its 3 products are CMP, [[1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-]], and glycerol.
This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase. This enzyme participates in glycerolipid metabolism.
References
- Pieringer J, Keech S, Pieringer RA (1981). "Biosynthesis in vitro of sialosylgalactosyldiacylglycerol by mouse brain microsomes". J. Biol. Chem. 256 (23): 12306–9. PMID 7298658.
- Weinstein J, de Souza-e-Silva U, Paulson JC (1982). "Purification of a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase and a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase to homogeneity from rat liver". J. Biol. Chem. 257 (22): 13835–44. PMID 7142179.
- Weinstein J, de Souza-e-Silva U, Paulson JC (1982). "Sialylation of glycoprotein oligosaccharides N-linked to asparagine Enzymatic characterization of a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase and a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase from rat liver". J. Biol. Chem. 257 (22): 13845–53. PMID 7142180.
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