GRAMD4
GRAM domain containing 4 (GRAMD4) also known as Death-Inducing Protein (DIP) is a protein that is encoded by the GRAMD4 gene.[5][6]
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| Aliases | GRAMD4, DIP, dA59H18.1, dJ439F8.1, GRAM domain containing 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 613691 MGI: 2676308 HomoloGene: 18199 GeneCards: GRAMD4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis.[7]
References
- GRCh38: Ensembl release 89: ENSG00000075240 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000035900 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: GRAM domain containing 4". Retrieved 2017-05-16.
- "RecName: Full=GRAM domain-containing protein 4; AltName: Full=Death-inducing protein". Retrieved 2020-03-07.
- Stanelle J, Tu-Rapp H, Pützer BM (2005). "A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53". Cell Death Differ. 12 (4): 347–57. doi:10.1038/sj.cdd.4401532. PMID 15565177. S2CID 24578301.
Further reading
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
- John K, Alla V, Meier C, Pützer BM (2011). "GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria". Cell Death Differ. 18 (5): 874–86. doi:10.1038/cdd.2010.153. PMC 3131914. PMID 21127500.
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