GBGT1
Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the GBGT1 gene.[5][6][7]
| GBGT1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | GBGT1, A3GALNT, FS, UNQ2513, globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group) | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 606074 MGI: 2449143 HomoloGene: 110677 GeneCards: GBGT1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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This gene encodes a member of the histo-blood group ABO gene family that encodes glycosyltransferases with related but distinct substrate specificity. This protein plays a role in synthesizing Forssman glycolipid (FG), a member of the globoseries glycolipid family. Human cells do not normally produce FG but produce the precursor glycolipids globotriaosylceramide and globoside. This protein may be involved in the tropism and binding of pathogenic organisms.[7]
References
- GRCh38: Ensembl release 89: ENSG00000148288 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000026829 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Xu H, Storch T, Yu M, Elliott SP, Haslam DB (October 1999). "Characterization of the human Forssman synthetase gene. An evolving association between glycolipid synthesis and host-microbial interactions". The Journal of Biological Chemistry. 274 (41): 29390–8. doi:10.1074/jbc.274.41.29390. PMID 10506200.
- Haslam DB, Baenziger JU (October 1996). "Expression cloning of Forssman glycolipid synthetase: a novel member of the histo-blood group ABO gene family". Proceedings of the National Academy of Sciences of the United States of America. 93 (20): 10697–702. Bibcode:1996PNAS...9310697H. doi:10.1073/pnas.93.20.10697. PMC 38217. PMID 8855242.
- "Entrez Gene: GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1".
Further reading
- Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, et al. (June 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
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