GAS2

GAS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V5R
Identifiers
Aliases	GAS2, growth arrest specific 2, GAS-2
External IDs	OMIM: 602835 MGI: 95657 HomoloGene: 31301 GeneCards: GAS2
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	22,813,001 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	51,644,723 bp[2]
RNA expression pattern
	Top expressed in
	trigeminal ganglion; ; liver; ; sural nerve; ; right lobe of liver; ; islet of Langerhans; ; Achilles tendon; ; spinal ganglia; ; body of pancreas; ; hair follicle; ; metanephric glomerulus;
	Top expressed in
	stria vascularis; ; proximal tubule; ; utricle; ; kidney; ; hand; ; cochlea; ; saccule; ; left lobe of liver; ; spermatocyte; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule binding; actin binding;
Cellular component	cytoskeleton; cytosol; actin filament; membrane; cytoplasm;
Biological process	cell cycle; regulation of cell shape; apoptotic process; initiation of primordial ovarian follicle growth; antral ovarian follicle growth; regulation of Notch signaling pathway; ovulation; basement membrane organization; microtubule cytoskeleton organization; actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	2620
	14453
	ENSG00000148935
	ENSMUSG00000030498
	O43903
	P11862
NM_001143830; NM_005256; NM_177553; NM_001351224; NM_001391933;
	NM_001391934; NM_001391935; NM_001391936; NM_001391937
	NM_008087; NM_001330607; NM_001330608
	NP_001137302; NP_005247; NP_808221; NP_001338153
	NP_001317536; NP_001317537; NP_032113
	Wikidata
View/Edit Human	View/Edit Mouse

Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.[5][6]

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[6]

References

GRCh38: Ensembl release 89: ENSG00000148935 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030498 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Collavin L, Buzzai M, Saccone S, Bernard L, Federico C, DellaValle G, Brancolini C, Schneider C (Jun 1998). "cDNA characterization and chromosome mapping of the human GAS2 gene". Genomics. 48 (2): 265–9. doi:10.1006/geno.1997.5172. PMID 9521882.
"Entrez Gene: GAS2 growth arrest-specific 2".

Olson RE, Morello JA, Kieff ED (1975). "Antibiotic treatment of oral anaerobic infections". Journal of Oral Surgery. 33 (8): 619–21. PMID 1056466.
Brancolini C, Bottega S, Schneider C (1992). "Gas2, a growth arrest-specific protein, is a component of the microfilament network system". J. Cell Biol. 117 (6): 1251–61. doi:10.1083/jcb.117.6.1251. PMC 2289493. PMID 1607387.
Schneider C, King RM, Philipson L (1988). "Genes specifically expressed at growth arrest of mammalian cells". Cell. 54 (6): 787–93. doi:10.1016/S0092-8674(88)91065-3. PMID 3409319. S2CID 37196421.
Sgorbissa A, Benetti R, Marzinotto S, et al. (2000). "Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis". J. Cell Sci. 112 (23): 4475–82. doi:10.1242/jcs.112.23.4475. PMID 10564664.
Benetti R, Del Sal G, Monte M, et al. (2001). "The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis". EMBO J. 20 (11): 2702–14. doi:10.1093/emboj/20.11.2702. PMC 125501. PMID 11387205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tsutsumi S, Kamata N, Vokes TJ, et al. (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMC 1182089. PMID 15124103.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Benetti R, Copetti T, Dell'Orso S, et al. (2005). "The calpain system is involved in the constitutive regulation of beta-catenin signaling functions". J. Biol. Chem. 280 (23): 22070–80. doi:10.1074/jbc.M501810200. PMID 15817486.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148935 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030498 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9521882-5] Collavin L, Buzzai M, Saccone S, Bernard L, Federico C, DellaValle G, Brancolini C, Schneider C (Jun 1998). "cDNA characterization and chromosome mapping of the human GAS2 gene". Genomics. 48 (2): 265–9. doi:10.1006/geno.1997.5172. PMID 9521882.

[entrez-6] "Entrez Gene: GAS2 growth arrest-specific 2".

GAS2

References

Further reading