Fructose-2,6-bisphosphate 2-phosphatase
The enzyme fructose-2,6-bisphosphate 2-phosphatase ({EC 3.1.3.46) catalyzes the reaction
- β-D-fructose 2,6-bisphosphate + H2O D-fructose 6-phosphate + phosphate
| fructose-2,6-bisphosphate 2-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.3.46 | ||||||||
| CAS no. | 81611-75-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is β-D-fructose-2,6-bisphosphate 2-phosphohydrolase. Other names in common use include fructose-2,6-bisphosphatase, and D-fructose-2,6-bisphosphate 2-phosphohydrolase. This enzyme participates in fructose and mannose metabolism.
Structural studies
As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1BIF, 1C7Z, 1C80, 1C81, 1FBT, 1K6M, 1TIP, 2AXN, 2BIF, 2DWO, 2DWP, 2I1V, and 3BIF.
References
- van Schaftingen E, Davies DR, Hers HG (1982). "Fructose-2,6-bisphosphatase from rat liver". Eur. J. Biochem. 124 (1): 143–9. doi:10.1111/j.1432-1033.1982.tb05917.x. PMID 6282585.
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