FMR1-AS1 gene

FMR1-AS1
Identifiers
Aliases	FMR1-AS1, ASFMR1, FMR1-AS, FMR1AS, FMR4, FMR1-AS1 gene, FMR1 antisense RNA 1, FMR1 antisense RNA 1 (head to head)
External IDs	OMIM: 300805 GeneCards: FMR1-AS1
Gene location (Human)
Chr.	X chromosome (human)[1]
End	147,911,817 bp[1]
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; lymph node; ; liver; ; skeletal muscle tissue; ; duodenum; ; prefrontal cortex; ; gallbladder; ; blood; ; Achilles tendon; ; urinary bladder;
	n/a
	More reference expression data
	n/a
Orthologs
	100126270
	n/a
	ENSG00000268066
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

In molecular biology, FMR1 antisense RNA 1 (FMR1-AS1), also known as ASFMR1 or FMR4, is a long non-coding RNA. The FMR1-AS1 gene overlaps, and is antisense to, the CGG repeat region of the FMR1 gene.[3] Its expression is upregulated in fragile X syndrome premutation carriers, and silenced in patients with fragile X syndrome.[3][4] FMR1-AS1 has an anti-apoptotic function.[4]

References

GRCh38: Ensembl release 89: ENSG00000268066 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ladd PD, Smith LE, Rabaia NA, Moore JM, Georges SA, Hansen RS, et al. (2007). "An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals". Hum Mol Genet. 16 (24): 3174–3187. doi:10.1093/hmg/ddm293. PMID 17921506.
Khalil AM, Faghihi MA, Modarresi F, Brothers SP, Wahlestedt C (2008). "A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome". PLOS ONE. 3 (1): e1486. Bibcode:2008PLoSO...3.1486K. doi:10.1371/journal.pone.0001486. PMC 2194623. PMID 18213394.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000268066 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17921506-3] Ladd PD, Smith LE, Rabaia NA, Moore JM, Georges SA, Hansen RS, et al. (2007). "An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals". Hum Mol Genet. 16 (24): 3174–3187. doi:10.1093/hmg/ddm293. PMID 17921506.

[pmid18213394-4] Khalil AM, Faghihi MA, Modarresi F, Brothers SP, Wahlestedt C (2008). "A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome". PLOS ONE. 3 (1): e1486. Bibcode:2008PLoSO...3.1486K. doi:10.1371/journal.pone.0001486. PMC 2194623. PMID 18213394.

FMR1-AS1 gene

See also

References