FLII

FLII
Identifiers
Aliases	FLII, FLI, FLIL, Fli1, actin remodeling protein, FLII actin remodeling protein
External IDs	OMIM: 600362 MGI: 1342286 HomoloGene: 11092 GeneCards: FLII
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	18,258,738 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	60,618,089 bp[2]
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; skeletal muscle tissue; ; spleen; ; pituitary gland; ; anterior pituitary; ; minor salivary gland; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; canal of the cervix; ; upper lobe of left lung;
	Top expressed in
	tracheobronchial tree; ; internal carotid artery; ; right lung lobe; ; extraocular muscle; ; epithelium of stomach; ; medullary collecting duct; ; renal corpuscle; ; external carotid artery; ; soleus muscle; ; trachea;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	actin binding; protein binding; actin filament binding;
Cellular component	cell junction; cytoskeleton; brush border; nucleus; focal adhesion; nucleoplasm; microtubule organizing center; cytoplasm; cytosol;
Biological process	multicellular organism development; actin filament severing; regulation of transcription, DNA-templated; actin cytoskeleton organization; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	2314
	14248
	ENSG00000177731; ENSG00000284571
	ENSMUSG00000002812
	Q13045
	Q9JJ28
	NM_001256264; NM_001256265; NM_002018
	NM_022009; NM_001302207
	NP_001243193; NP_001243194; NP_002009
	NP_001289136; NP_071292
	Wikidata
View/Edit Human	View/Edit Mouse

Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene.[5][6]

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain.[7] The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[6]

Interactions

FLII has been shown to interact with LRRFIP1[8][9] and TRAF interacting protein.[10]

References

ENSG00000284571 GRCh38: Ensembl release 89: ENSG00000177731, ENSG00000284571 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000002812 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Chen KS, Gunaratne PH, Hoheisel JD, Young IG, Miklos GL, Greenberg F, Shaffer LG, Campbell HD, Lupski JR (Feb 1995). "The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2". Am J Hum Genet. 56 (1): 175–82. PMC 1801336. PMID 7825574.
"Entrez Gene: FLII flightless I homolog (Drosophila)".
Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.
Liu, Y T; Yin H L (Apr 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. ISSN 0021-9258. PMID 9525888.
Fong, K S; de Couet H G (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. ISSN 0888-7543. PMID 10366446.
Wilson, S A; Brown E C; Kingsman A J; Kingsman S M (Aug 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. ISSN 0305-1048. PMC 147727. PMID 9671805.

Campbell HD, Schimansky T, Claudianos C, et al. (1994). "The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11386–90. Bibcode:1993PNAS...9011386C. doi:10.1073/pnas.90.23.11386. PMC 47987. PMID 8248259.
Campbell HD, Fountain S, Young IG, et al. (1997). "Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL". Genomics. 42 (1): 46–54. doi:10.1006/geno.1997.4709. PMID 9177775.
Liu YT, Yin HL (1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. PMID 9525888.
Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I." Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. PMC 147727. PMID 9671805.
Fong KS, de Couet HG (1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.
Davy DA, Campbell HD, Fountain S, et al. (2001). "The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases". J. Cell Sci. 114 (Pt 3): 549–62. doi:10.1242/jcs.114.3.549. PMID 11171324.
Campbell HD, Fountain S, McLennan IS, et al. (2002). "Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development". Mol. Cell. Biol. 22 (10): 3518–26. doi:10.1128/MCB.22.10.3518-3526.2002. PMC 133791. PMID 11971982.
Bi W, Yan J, Stankiewicz P, et al. (2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC 186594. PMID 11997338.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Lee YH, Campbell HD, Stallcup MR (2004). "Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity". Mol. Cell. Biol. 24 (5): 2103–17. doi:10.1128/MCB.24.5.2103-2117.2004. PMC 350567. PMID 14966289.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wang T, Chuang TH, Ronni T, et al. (2006). "Flightless I homolog negatively modulates the TLR pathway". J. Immunol. 176 (3): 1355–62. doi:10.4049/jimmunol.176.3.1355. PMID 16424162.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] ENSG00000284571 GRCh38: Ensembl release 89: ENSG00000177731, ENSG00000284571 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002812 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7825574-5] Chen KS, Gunaratne PH, Hoheisel JD, Young IG, Miklos GL, Greenberg F, Shaffer LG, Campbell HD, Lupski JR (Feb 1995). "The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2". Am J Hum Genet. 56 (1): 175–82. PMC 1801336. PMID 7825574.

[entrez-6] "Entrez Gene: FLII flightless I homolog (Drosophila)".

[pmid24155256-7] Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.

[pmid9525888-8] Liu, Y T; Yin H L (Apr 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. ISSN 0021-9258. PMID 9525888.

[pmid10366446-9] Fong, K S; de Couet H G (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. ISSN 0888-7543. PMID 10366446.

[pmid9671805-10] Wilson, S A; Brown E C; Kingsman A J; Kingsman S M (Aug 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. ISSN 0305-1048. PMC 147727. PMID 9671805.

FLII

Interactions

References

Further reading