Eduardo Arzt

Eduardo Arzt (born February 22, 1953) is an Argentine molecular biologist, Master in Experimental Biology, Doctor (Ph.D) from the Faculty of Pharmacy and Biochemistry (University of Buenos Aires). Currently, he is a senior researcher at CONICET, distinguished professor of the Faculty of Natural Sciences of the University of Buenos Aires, External Scientific Member of the Max Planck Society (Germany) and director of the Biomedicine Research Institute of Buenos Aires[1] – CONICET – Partner Institute of the Max Planck Society.

Eduardo Arzt
Born (1953-02-22) 22 February 1953
Buenos Aires, Argentina
NationalityArgentine
AwardsGuggenheim Fellowship, Houssay award, Bunge y Born award, Konex award
Scientific career
FieldsMolecular Biology
InstitutionsCONICET, Max Planck Society, UBA

Contribution and recognition

His scientific contributions stand him out as an internationally recognized personality in the field of molecular neuroendocrinology. His laboratory contributed to the discovery of new genes and pathways involved in the physiological adaptation to homeostasis in response to stress,[2][3] hypoxia (lack of cellular oxygen),[4][5] physiopathological processes (pituitary tumors),[6][7][8][9][10][11][12][13][14] and to the discovery of new targets for pharmacological treatments.[15][16][17][18]

He is known not only for his findings, which are an example of research in biomedicine, transferring results from basic molecular biology to pharmacological applications,[19][20][21] but also for his vast institutional achievements for Argentine and Latin-American science,[22] including an active and important role in the development and realization of the project of the Polo Científico Tecnológico[23] and the creation of the Biomedicine Research Institute of Buenos Aires[24][25] – CONICET – Partner Institute of the Max Planck Society. He has received, for its ongoing work, both prestigious Argentine (Bunge and Born Award, Houssay Award) and International (Guggenheim Fellowship, External Scientific Member of the Max Planck Society, Order of Merit of the Federal Republic of Germany, Berthold Medal, TWAS Prize)[25][26] awards and distinctions.

Bibliographic review / career

In 1970 he graduated from the Colegio Nacional de Buenos Aires, Argentina. The following year, he enrolled at the Faculty of Pharmacy and Biochemistry of the University of Buenos Aires, and graduated in 1978.

In 1981 he began a Masters in Experimental Biology at the Universidad Autonoma Metropolitana, Mexico, and his Master's Thesis was on transportation models in biological membranes (1984).

From 1985 to 1988 at the UBA Faculty of Pharmacy and Biochemistry, he conducted his Ph.D. in cellular mechanisms involved in immune-neuroendocrine pathways, at the Institute for Medical Research A. Lanari, of the Faculty of Medicine (UBA).

In 1989 he joined the Scientific Researcher Career of CONICET, Argentina, where he is now a Senior Researcher.[27]

In 1995 he obtained the position of Professor in Molecular and Cellular Biology, Faculty of Natural Sciences (UBA).

In 1997 he participated as co-Founder and Director of the Laboratorio de Fisiología y Biología Molecular (LFBM-FCEN-UBA) [Laboratory of Physiology and Molecular Biology].

In 2005 he was appointed External Scientific Member of the Max Planck Society.[28][29]

In 2007 he participated in the agreement for the establishment of the Biomedicine Research Institute of Buenos Aires – CONICET – Partner Institute of the Max Planck Society (IBioBA),[1] whose construction was completed in 2012 at the Polo Científico y Tecnológico.[30]

Awards and distinctions
  • 1987 – UAM – México, in the field of Biological Sciences and Health. Prize for his master thesis "Formation of oligomers of ion transporters by Nigericin".
  • 1993 – Award: cover of the journal Endocrinology Vol. 132.
  • 1997 – Guggenheim fellowship, awarded by the John Simon Guggenheim Memorial Foundation. Nueva York, United States.[31]
  • 1997 – "Lucio Cherny" award, for the best presentation, XLII Congress of Clinical Research Argentine Society, Mar del Plata.
  • 2001 – The presentation "Transcriptional regulation of the gp130 cytokine IL-6 by PACAP and estrogens: its importance for anterior pituitary pathophysiology" was selected as "hot topic" in the 7th International Pituitary Congress. Phoenix- United States
  • 2002 – "Lucio Cherny" award for the best presentation, XLVII XLII Congress of Clinical Research Argentine Society, Mar del Plata.
  • 2003 – "Bernardo Houssay, to Scientific and Technological Research" award, Ministry of Science and Technology, Argentina.
  • 2005 – Appointed External Scientific Member of the Max Planck Society, Germany.[28][29]
  • 2006 – Award: cover of the journal Trends Pharmacol Sci.
  • 2008 – Bunge and Born award. Experimental Medicine.[32][33][34]
  • 2011 – Federal Cross of Merit of the Federal Republic of Germany for the commitment to the development of scientific cooperation between Germany and Argentina, and by participation in the founding of the binational Biomedicine Max Planck Institute in Buenos Aires.[25][26]
  • 2011 – Award: Cover of the journal Neuroendocrinology Vol. 94.
  • 2013 – Konex award, Argentina. Molecular Biology and biochemistry.[35]
  • 2015 – TWAS Prize in Medical Sciences.[36]
  • 2017 – Berthold Medal, awarded by the German Society for Endocrinology.[37]

References
  1. Biomedicine Research Institute of Buenos Aires - CONICET - MPSP - official website.
  2. Refojo D, Echenique C, Müller MB, et al. (April 2005). "Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas". Proceedings of the National Academy of Sciences of the United States of America. 102 (17): 6183–8. Bibcode:2005PNAS..102.6183R. doi:10.1073/pnas.0502070102. PMC 1087957. PMID 15833812.
  3. Arzt E, Holsboer F (October 2006). "CRF signaling: molecular specificity for drug targeting in the CNS". Trends in Pharmacological Sciences. 27 (10): 531–8. doi:10.1016/j.tips.2006.08.007. PMID 16935354.
  4. Druker J, Liberman AC, Antunica-Noguerol M, et al. (June 2013). "RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity". Molecular and Cellular Biology. 33 (11): 2116–27. doi:10.1128/MCB.01470-12. PMC 3648064. PMID 23508108.
  5. Carbia-Nagashima A, Gerez J, Perez-Castro C, et al. (October 2007). "RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia". Cell. 131 (2): 309–23. doi:10.1016/j.cell.2007.07.044. hdl:20.500.12110/paper_00928674_v131_n2_p309_CarbiaNagashima. PMID 17956732. S2CID 12486303.
  6. Arzt E, Stelzer G, Renner U, Lange M, Müller OA, Stalla GK (November 1992). "Interleukin-2 and interleukin-2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures". The Journal of Clinical Investigation. 90 (5): 1944–51. doi:10.1172/JCI116072. PMC 443256. PMID 1331177.
  7. Arzt E, Buric R, Stelzer G, et al. (January 1993). "Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6". Endocrinology. 132 (1): 459–67. doi:10.1210/endo.132.1.8419142. PMID 8419142.
  8. Arzt E, Pereda MP, Castro CP, Pagotto U, Renner U, Stalla GK (January 1999). "Pathophysiological role of the cytokine network in the anterior pituitary gland". Frontiers in Neuroendocrinology. 20 (1): 71–95. doi:10.1006/frne.1998.0176. PMID 9882537. S2CID 42782633.
  9. Arzt E (December 2001). "gp130 cytokine signaling in the pituitary gland: a paradigm for cytokine-neuro-endocrine pathways". The Journal of Clinical Investigation. 108 (12): 1729–33. doi:10.1172/JCI14660. PMC 209477. PMID 11748253.
  10. Giacomini D, Páez-Pereda M, Stalla J, Stalla GK, Arzt E (July 2009). "Molecular interaction of BMP-4, TGF-beta, and estrogens in lactotrophs: impact on the PRL promoter". Molecular Endocrinology. 23 (7): 1102–14. doi:10.1210/me.2008-0425. PMC 5419174. PMID 19342445.
  11. Perez-Castro C, Renner U, Haedo MR, Stalla GK, Arzt E (January 2012). "Cellular and molecular specificity of pituitary gland physiology". Physiological Reviews. 92 (1): 1–38. doi:10.1152/physrev.00003.2011. hdl:11336/68927. PMID 22298650. S2CID 73834.
  12. Paez-Pereda M, Giacomini D, Refojo D, et al. (February 2003). "Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk". Proceedings of the National Academy of Sciences of the United States of America. 100 (3): 1034–9. Bibcode:2003PNAS..100.1034P. doi:10.1073/pnas.0237312100. PMC 298721. PMID 12552124.
  13. Arzt E, Chesnokova V, Stalla GK, Melmed S (March 2009). "Pituitary adenoma growth: a model for cellular senescence and cytokine action". Cell Cycle. 8 (5): 677–8. doi:10.4161/cc.8.5.8065. PMC 2710531. PMID 19223763.
  14. Antunica-Noguerol, M; Budziñski, M L; Druker, J; Gassen, N C; Sokn, M C; Senin, S; Aprile-Garcia, F; Holsboer, F; Rein, T (2016-05-13). "The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51". Cell Death and Differentiation. 23 (10): 1579–1591. doi:10.1038/cdd.2016.44. ISSN 1476-5403. PMC 5041187. PMID 27177020.
  15. Giacomini D, Páez-Pereda M, Theodoropoulou M, et al. (January 2006). "Bone morphogenetic protein-4 inhibits corticotroph tumor cells: involvement in the retinoic acid inhibitory action". Endocrinology. 147 (1): 247–56. doi:10.1210/en.2005-0958. PMID 16195406.
  16. Castillo V, Giacomini D, Páez-Pereda M, et al. (September 2006). "Retinoic acid as a novel medical therapy for Cushing's disease in dogs". Endocrinology. 147 (9): 4438–44. doi:10.1210/en.2006-0414. PMID 16740975.
  17. Páez-Pereda, Marcelo; Arzt, Eduardo; Stalla, Günter K (2002). "Cushing's syndrome: Drug targets and therapeutic options". Expert Opinion on Therapeutic Patents. 12 (10): 1537–46. doi:10.1517/13543776.12.10.1537. S2CID 71327660.
  18. Gerez, J; Tedesco, L; Bonfiglio, J J; Fuertes, M; Barontini, M; Silberstein, S; Wu, Y; Renner, U; Páez-Pereda, M (2014-12-15). "RSUME inhibits VHL and regulates its tumor suppressor function". Oncogene. 34 (37): 4855–4866. doi:10.1038/onc.2014.407. ISSN 1476-5594. PMID 25500545.
  19. Descubren un gen maestro para entender la maquinaria celular, by Nora Bär. Diario La Nación (Argentina), 10/19/2007. (spanish)
  20. Científicos argentinos hallan un gen maestro para luchar contra el cáncer, by Valeria Román. Diario Clarín (Argentina), 10/19/2007. (spanish)
  21. Prueban con éxito una terapia para la enfermedad de Cushing, Diario La Nación (Argentina), 10/13/2006.
  22. Arzt E (November 2012). "Collaboration: Biomedical network in South America". Nature. 491 (7424): 333. Bibcode:2012Natur.491..333A. doi:10.1038/491333d. PMID 23151571.
  23. Ciencia entre Palermo Soho y Palermo Hollywood Archived 2014-03-11 at the Wayback Machine, by Paula Rodriguez, Deutsche Welle site, 12/21/2009.
  24. Primer Mundo, en Palermo: el imponente Instituto Max Planck, by Nora Bär, Diario La Nación(Argentina), 11/26/2012. (spanish)
  25. Centro Alemán de Información para Latinoamérica y España Archived 2014-03-11 at the Wayback Machine – official website.
  26. Orden del Mérito, Página 12 (Argentina), 07/20/2011. (spanish)
  27. "Comunicación | Conicet". www.conicet.gov.ar (in European Spanish). Retrieved 2017-11-17.
  28. Max Planck Institute Psychiatry Munich Archived 2014-03-11 at the Wayback Machine.
  29. Importante distinción a dos científicos argentinos, by Nora Bär, Diario La Nación (Argentina), 08/09/2005. (spanish)
  30. Polo Científico Tecnológico - official website. (spanish)
  31. John Simon Guggenheim Memorial Foundation Archived 2014-02-26 at the Wayback Machine.
  32. Fundación Bunge y Born Archived 2014-03-11 at the Wayback Machine – web site. Experimental medicine award.
  33. Premio Bunge y Born a dos investigadores del CONICET, by Nora Bär, Diario La Nación (Argentina), 05/23/2008. (spanish)
  34. Premio Bunge y Born para un prestigioso investigador, by Valeria Román, Diario Clarín (Argentina), 08/13/2008. (spanish)
  35. Fundación Konex, official website. Konex award 2013: Molecular Biology and Biochemistry.
  36. "Prizes and Awards". The World Academy of Sciences. 2016.
  37. "Eduardo Arzt awarded the Berthold Medal". www.psych.mpg.de. Retrieved 2017-11-17.
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