EPHA10

EPH receptor A10 is a protein in humans that is encoded by the EPHA10 gene.[5]

EPHA10
Identifiers
Aliases	EPHA10, EPH receptor A10
External IDs	OMIM: 611123 MGI: 3586824 HomoloGene: 67804 GeneCards: EPHA10
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 37,713,880 bp[1] End 37,765,133 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 124,880,899 bp[2] End 124,917,800 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm rectum Brodmann area 9 nucleus accumbens pituitary gland prefrontal cortex oocyte anterior pituitary secondary oocyte hypothalamus Top expressed in piriform cortex superior colliculus ventral tegmental area superior frontal gyrus pontine nuclei medial vestibular nucleus medial dorsal nucleus dorsal tegmental nucleus inferior colliculus lateral hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity transmembrane-ephrin receptor activity kinase activity protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding ephrin receptor activity receptor tyrosine kinase transmembrane signaling receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular region cytoplasm neuron projection receptor complex Biological process phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway protein phosphorylation peptidyl-tyrosine phosphorylation ephrin receptor signaling pathway biological process negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 284656 230735 Ensembl ENSG00000183317 ENSMUSG00000028876 UniProt Q5JZY3 Q8BYG9 RefSeq (mRNA) NM_001004338 NM_001099439 NM_173641 NM_001256432 NM_177671 RefSeq (protein) NP_001092909 NP_775912 NP_001243361 NP_808339 Location (UCSC) Chr 1: 37.71 – 37.77 Mb Chr 4: 124.88 – 124.92 Mb PubMed search [3] [4]
Wikidata
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Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells.[5]