Lipid IVA 3-deoxy-D-manno-octulosonic acid transferase

Lipid IVA 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.12, KDO transferase, waaA (gene), kdtA (gene), 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase, lipid IVA KDO transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

lipid IVA + CMP-alpha-Kdo alpha-Kdo-(2->6)-lipid IVA + CMP
Lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
Identifiers
EC no.2.4.99.12
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
PRIAMprofile
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NCBIproteins

The bifunctional enzyme from Escherichia coli transfers two 3-deoxy-D-man no-oct-2-resonate residues to lipid IVA.

See also
  • EC 2.4.99.13, (KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase

References
  1. Belunis CJ, Raetz CR (May 1992). "Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli". The Journal of Biological Chemistry. 267 (14): 9988–97. PMID 1577828.
  2. Mamat U, Schmidt H, Munoz E, Lindner B, Fukase K, Hanuszkiewicz A, Wu J, Meredith TC, Woodard RW, Hilgenfeld R, Mesters JR, Holst O (August 2009). "WaaA of the hyperthermophilic bacterium Aquifex aeolicus is a monofunctional 3-deoxy-D-manno-oct-2-ulosonic acid transferase involved in lipopolysaccharide biosynthesis". The Journal of Biological Chemistry. 284 (33): 22248–62. doi:10.1074/jbc.M109.033308. PMC 2755949. PMID 19546212.
  3. White KA, Kaltashov IA, Cotter RJ, Raetz CR (June 1997). "A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae". The Journal of Biological Chemistry. 272 (26): 16555–63. doi:10.1074/jbc.272.26.16555. PMID 9195966.
  4. Löbau S, Mamat U, Brabetz W, Brade H (November 1995). "Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-alpha-D-man no-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183". Molecular Microbiology. 18 (3): 391–9. doi:10.1111/j.1365-2958.1995.mmi_18030391.x. PMID 8748024.
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