Dioxotetrahydropyrimidine phosphoribosyltransferase
In enzymology, a dioxotetrahydropyrimidine phosphoribosyltransferase (EC 2.4.2.20) is an enzyme that catalyzes the chemical reaction
- a 2,4-dioxotetrahydropyrimidine D-ribonucleotide + diphosphate a 2,4-dioxotetrahydropyrimidine + 5-phospho-alpha-D-ribose 1-diphosphate
| dioxotetrahydropyrimidine phosphoribosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.2.20 | ||||||||
| CAS no. | 37277-75-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 2,4-dioxotetrahydropyrimidine D-ribonucleotide and diphosphate, whereas its two products are 2,4-dioxotetrahydropyrimidine and 5-phospho-alpha-D-ribose 1-diphosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is 2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase. Other names in common use include dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase, dioxotetrahydropyrimidine phosphoribosyl transferase, and dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase.
References
- HATFIELD D, WYNGAARDEN JB (1964). "3-RIBOSYLPURINES. I. SYNTHESIS OF (3-RIBOSYLURIC ACID) 5'-PHOSPHATE AND (3-RIBOSYLXANTHINE) 5'-PHOSPHATE BY A PYRIMIDINE RIBONUCLEOTIDE PYROPHOSPHORYLASE OF BEEF ERYTHROCYTES". J. Biol. Chem. 239: 2580–6. PMID 14235538.