Dimethylhistidine N-methyltransferase
In enzymology, a dimethylhistidine N-methyltransferase (EC 2.1.1.44) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine S-adenosyl-L-homocysteine + Nalpha,Nalpha,Nalpha-trimethyl-L-histidine
| dimethylhistidine N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.44 | ||||||||
| CAS no. | 62213-53-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are S-adenosyl methionine and Nalpha,Nalpha-dimethyl-L-histidine, whereas its two products are S-adenosylhomocysteine and Nalpha,Nalpha,Nalpha-trimethyl-L-histidine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine Nalpha-methyltransferase. Other names in common use include dimethylhistidine methyltransferase, histidine-alpha-N-methyltransferase, S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine, and alpha-N-methyltransferase.
References
- Ishikawa Y, Melville DB (1970). "The enzymatic alpha-N-methylation of histidine". J. Biol. Chem. 245 (22): 5967–73. PMID 5484456.