Diethylstilbestrol dilaurate

Diethylstilbestrol dilaurate (brand name Acnestrol-Lotion) is a synthetic, nonsteroidal estrogen of the stilbestrol group and an ester of diethylstilbestrol (DES) that was previously marketed but is now no longer available.[1][2] It was formulated and used as a micronized topical medication to treat acne in adolescent boys and young men.[2][3] The drug was marketed as early as 1951.[4]

Not to be confused with Broparestrol.
Diethylstilbestrol dilaurate
Clinical data
Trade namesAcnestrol-Lotion
Identifiers
  • 4-[(3E)-4-[4-(Dodecanoyloxy)phenyl]hex-3-en-3-yl]phenyl dodecanoate
Chemical and physical data
FormulaC42H64O4
Molar mass632.970 g·mol−1
3D model (JSmol)
  • CCCCCCCCCCCC(=O)OC1=CC=C(C=C1)C(\CC)=C(/CC)C1=CC=C(OC(=O)CCCCCCCCCCC)C=C1
  • InChI=1S/C42H64O4/c1-5-9-11-13-15-17-19-21-23-25-41(43)45-37-31-27-35(28-32-37)39(7-3)40(8-4)36-29-33-38(34-30-36)46-42(44)26-24-22-20-18-16-14-12-10-6-2/h27-34H,5-26H2,1-4H3/b40-39+
  • Key:GEWSRLGHTICJOA-XQQUEIPISA-N

References
  1. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 397. ISBN 978-1-4757-2085-3.
  2. Canadian Pharmaceutical Association (1963). Compendium of pharmaceutical specialties (Canada) 1963. Canadian Pharmaceutical Association. p. 14.
  3. Frank SB (1971). Acne Vulgaris. Thomas. p. 259. ISBN 9780398006020.
  4. New York State Journal of Medicine. Medical Society of the State of New York. April 1951. p. 1313.


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