Diacylglycerol—sterol O-acyltransferase
In enzymology, a diacylglycerol-sterol O-acyltransferase (EC 2.3.1.73) is an enzyme that catalyzes the chemical reaction
- 1,2-diacyl-sn-glycerol + sterol monoacylglycerol + sterol ester
| diacylglycerol-sterol O-acyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.73 | ||||||||
| CAS no. | 79586-23-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 1,2-diacyl-sn-glycerol and sterol, whereas its two products are monoacylglycerol and sterol ester.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 1,2-diacyl-sn-glycerol:sterol O-acyltransferase. This enzyme is also called 1,2-diacyl-sn-glycerol:sterol acyl transferase. This enzyme participates in bile acid biosynthesis.
References
- Bartlett K, Keat MJ, Mercer EI (1974). "Biosynthesis of sterol esters in Phycomyces blakesleeanus". Phytochemistry. 13: 1107–1113. doi:10.1016/0031-9422(74)80083-X.
- Garcia RE, Mudd JB (1978). "Metabolism of monoacylglycerol and diacylglycerol by enzyme preparations from spinach leaves". Arch. Biochem. Biophys. 191 (2): 487–93. doi:10.1016/0003-9861(78)90387-9. PMID 742884.
- Garcia RE; Mudd JB (1981). "1,2-Diacyl-sn-glycerol:sterol acyl transferase from spinach leaves (Spinacia oleracea L.)". Methods Enzymol. 71: 768–772. doi:10.1016/0076-6879(81)71090-5.
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