Deoxyribonuclease (pyrimidine dimer)
Deoxyribonuclease (pyrimidine dimer) (EC 3.1.25.1, endodeoxyribonuclease (pyrimidine dimer), bacteriophage T4 endodeoxyribonuclease V, T4 endonuclease V) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction:
- Endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
| Deoxyribonuclease (pyrimidine dimer) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.25.1 | ||||||||
| CAS no. | 66143-22-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme acts on a damaged strand, 5' from the damaged site.
References
- Braun AG, Radman M, Grossman L (September 1976). "Enzymatic repair of DNA: SITES OF HYDROLYSIS BY THE Escherichia coli endonuclease specific for pyrimidine dimers (correndonuclease II)". Biochemistry. 15 (18): 4116–20. doi:10.1021/bi00663a031. PMID 786366.
- Riazuddin S, Grossman L (September 1977). "Micrococcus luteus correndonucleases. II. Mechanism of action of two endonucleases specific for DNA containing pyrimidine dimers". The Journal of Biological Chemistry. 252 (18): 6287–93. doi:10.1016/S0021-9258(17)39953-2. PMID 330526.
External links
- Deoxyribonuclease+(pyrimidine+dimer) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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