Deoxycytidylate 5-hydroxymethyltransferase
In enzymology, a deoxycytidylate 5-hydroxymethyltransferase (EC 2.1.2.8) is an enzyme that catalyzes the chemical reaction
- 5,10-methylenetetrahydrofolate + H2O + deoxycytidylate tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
| deoxycytidylate 5-hydroxymethyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.2.8 | ||||||||
| CAS no. | 9012-68-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, H2O, and deoxycytidylate, whereas its two products are tetrahydrofolate and 5-hydroxymethyldeoxycytidylate.
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase. Other names in common use include dCMP hydroxymethylase, d-cytidine 5'-monophosphate hydroxymethylase, deoxyCMP hydroxymethylase, deoxycytidylate hydroxymethylase, and deoxycytidylic hydroxymethylase. This enzyme participates in pyrimidine metabolism and one carbon pool by folate.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1B49, 1B5D, and 1B5E.
References
- Mathews CK, Brown F, Cohen SS (1964). "Virus-induced acquisition of metabolic function. VII. Biosynthesis de novo of deoxycytidylate hydroxymethylase". J. Biol. Chem. 239: 2957–2963. PMID 14217882.