David Taylor (professor)

David Taylor FFRPS FRPharmS (born 1963) is a British professor. He is the head of the Pharmaceutical Sciences Clinical Academic Group within King's Health Partners. Taylor has been lead author and editor of the Maudsley Prescribing Guidelines in Psychiatry since 1994. In 2014, Taylor was named as one of the top 100 clinical leaders in the UK National Health Service.[1]

14th Edition June 2021
1st Edition 2020

Early life and education

Taylor was born in Leicester in 1963 and attended Loughborough Grammar School (1975-1982). He is the second of four brothers. His younger brother is the presenter and historian, Stephen Taylor.[2] His father, James Taylor CChem MRSC, contributed to the development of sodium cromoglycate.[3]

Taylor was guitarist in New Wave group The Thought Police, who supported Theatre of Hate on their 1981 UK tour.

A keen rugby player, Taylor played three seasons for Loughborough Grammar School first team and was later captain of Old Pauline FC 1st XV, for whom he made over 300 appearances, many alongside fellow Old Loughburian Patrick MacLarnon.

In 2023, Taylor completed the London Marathon in just over four hours.

Taylor obtained a BSc in pharmacy and an MSc in clinical pharmacy from the University of Brighton. He later gained a PhD in clinical pharmacology at King’s College, London. He is a fellow of the Royal Pharmaceutical Society of Great Britain (FRPharmS),[4] a fellow of that organisation’s faculty (FFRPS) and an elected fellow of the Royal College of Physicians, Edinburgh (FRCPEdin). In 2021 he was made an honorary fellow of the Royal College of Psychiatrists (FRCPsych Hon) in recognition of his "outstanding contribution to the profession and the cause of mental health".

Career

Taylor's first experience in psychiatry was in 1986 – a brief placement at the Towers Hospital in Leicester. He then worked in general medicine at hospitals in London and Sydney until joining the Maudsley hospital in 1993. In 1997 Taylor founded the national centre for information on drugs in psychiatry, part of the UKMi network. He has been head of pharmacy since 1995 and Director of Pharmacy and Pathology at the South London and Maudsley NHS Foundation Trust since 2000.

In 2008, Taylor was awarded a chair in psychopharmacology at King’s College, London and also made honorary professor at the Institute of Psychiatry. Since 2010, Taylor has been head of the Pharmaceutical Sciences Clinical Academic Group within King's Health Partners.[5]

Public works

Taylor was chairman of the UK Psychiatric Pharmacy Group (1997-1999) and the foundation president of the College of Mental Health Pharmacists, a role recognised by the award of a lifetime fellowship (FCMHP). He was a member of the government-appointed panel which brought in laws in drug driving[6] and is currently a member of the Advisory Council on the Misuse of Drugs.[7]

Taylor has been a member of several NICE panels responsible for drawing up treatment guidelines in mental health, including the 2022 guideline on depression in adults.[8]

Since 2011 he has been editor-in-chief of the journal Therapeutic Advances in Psychopharmacology[9] which was launched in the same year. The journal has an official Impact Factor of 4.2[10] and is ranked 64th out of 155 psychiatry journals.

Taylor is widely recognised as an expert witness on the effect of drugs on behaviour and has given testimony on over two hundred civil and criminal cases.

Research

Taylor has authored around 400 papers (H index 72) in journals such as the Lancet, BMJ, British Journal of Psychiatry and Journal of Clinical Psychiatry, on subjects ranging from the value of long-acting antipsychotic injections,[11][12] the efficacy of psilocybin as an antidepressant and the efficacy and safety of agomelatine. Taylor’s research has helped further understanding of the use of clozapine.[13][14][15][16][17] In 2022 he suggested a refined phenotype for genetic studies into clozapine-related agranulocytosis.[18] He has also developed a genetic test predicting response to clozapine and the risk of agranulocytosis. This test is marketed in the UK by Psychiatric Genetics Ltd. Most recently Taylor has tackled the controversial subjects of discontinuation of antidepressants[19][20] and antipsychotics.[21][22] He is co-founder of 428 Pharma a company developing the world's first antidepressant long-acting injection which is designed for use both as longterm treatment and, at different dosage levels, as a means of successfully withdrawing from antidepressant treatment.

Maudsley Prescribing Guidelines

Taylor was the originator of the idea of an evidenced-based mental health prescribing guideline along with the late professor Robert Kerwin and has made a major and unique contribution by writing the Maudsley Prescribing Guidelines[23] for 25 years. Taylor is the de facto editor of this publication and is the only author to be credited on all 14 editions. The Maudsley Prescribing Guidelines[24][25][26] have sold over 300,000 copies in thirteen languages. The 14th edition was published in June 2021. He has also co-written three other books in the Maudsley Prescribing Guidelines series.

Lectures

Professor Taylor has lectured throughout the world, including tours of New Zealand (2011), Hong Kong (2016), Australia (2019) and Japan (2019). He was a keynote speaker at the 2018 annual meeting of Royal Australian and New Zealand College of Psychiatrists in Auckland, at the Royal College of Psychiatrists annual meeting in London in 2019,[27] and at The 119th Annual Meeting of the Japanese Society of Psychiatry and Neurology in 2023.

Selected publications

References
  1. Trivedi, Shreshtha. "Clinical leaders 2014". Health Service Journal.
  2. "TV & Media". Stephen Taylor, WW2 Relic Hunter. 18 January 2018. Retrieved 31 January 2023.
  3. Bell, J. H.; Stevenson, N. A.; Taylor, J. E. (1973). "A moisture transfer effect in hard gelatin capsules of sodium cromoglycate". The Journal of Pharmacy and Pharmacology. 25: Suppl:96P–103. PMID 4150598.
  4. "Society appoints 24 new Fellows". Royal Pharmaceutical Society of Great Britain. London. 11 December 2009. Retrieved 3 June 2021.
  5. "Professor David Taylor MSc PhD FFRPS FRPharmS". King's People. King's College London. Retrieved 3 June 2021.
  6. Expert Panel of Drug Driving (March 2013). DRIVING UNDER THE INFLUENCE OF DRUGS (PDF). Department for Transport (DfT) (Report).
  7. "Advisory Council on the Misuse of Drugs Membership". GOV.UK. Retrieved 3 June 2021.
  8. https://www.nice.org.uk/guidance/ng222/documents/committee-member-list-2
  9. "Therapeutic Advances in Psychopharmacology Editorial Team". SAGE Journals. Retrieved 3 June 2021.
  10. "Journal Indexing and Metrics: Therapeutic Advances in Psychopharmacology". journals.sagepub.com. 29 June 2023. Retrieved 29 June 2023.
  11. Taylor, D. M.; Sparshatt, A.; O’Hagan, M.; Dzahini, O. (September 2016). "Effect of paliperidone palmitate on hospitalisation in a naturalistic cohort – a four-year mirror image study". European Psychiatry. 37: 43–48. doi:10.1016/j.eurpsy.2016.04.009. ISSN 0924-9338. PMID 27447102. S2CID 13769572.
  12. Taylor, D.; Fischetti, C.; Sparshatt, A.; Thomas, A.; Bishara, D.; Cornelius, V. (2009). "Risperidone long-acting injection: a 6-year mirror-image study of healthcare resource use". Acta Psychiatrica Scandinavica. 120 (2): 97–101. doi:10.1111/j.1600-0447.2009.01352.x. ISSN 1600-0447. PMID 19207128. S2CID 39369119.
  13. Bachmann, C. J.; Aagaard, L.; Bernardo, M.; Brandt, L.; Cartabia, M.; Clavenna, A.; Fusté, A. Coma; Furu, K.; Garuoliené, K.; Hoffmann, F.; Hollingworth, S. (2017). "International trends in clozapine use: a study in 17 countries". Acta Psychiatrica Scandinavica. 136 (1): 37–51. doi:10.1111/acps.12742. ISSN 1600-0447. PMID 28502099. S2CID 206969000.
  14. Taylor, David (August 1997). "Pharmacokinetic interactions involving clozapine". The British Journal of Psychiatry. 171 (2): 109–112. doi:10.1192/bjp.171.2.109. ISSN 0007-1250. PMID 9337943. S2CID 5033129.
  15. Oloyede, Ebenezer; Casetta, Cecilia; Dzahini, Olubanke; Segev, Aviv; Gaughran, Fiona; Shergill, Sukhi; Mijovic, Alek; Helthuis, Marinka; Whiskey, Eromona; MacCabe, James Hunter; Taylor, David (2021). "There Is Life After the UK Clozapine Central Non-Rechallenge Database". Schizophrenia Bulletin. 47 (4): 1088–1098. doi:10.1093/schbul/sbab006. PMC 8266568. PMID 33543755.
  16. Whiskey, Eromona; Barnard, Alex; Oloyede, Ebenezer; Dzahini, Olubanke; Taylor, David M.; Shergill, Sukhwinder S. (2021). "An evaluation of the variation and underuse of clozapine in the United Kingdom". Acta Psychiatrica Scandinavica. 143 (4): 339–347. doi:10.1111/acps.13280. ISSN 1600-0447. PMID 33501659.
  17. Taylor, David; Atkins, Matthew; Harland, Robert; Baburina, Irina; MacCabe, James H.; Salamone, Salvatore J.; McGuire, Philip (March 2021). "Point-of-care measurement of clozapine concentration using a finger-stick blood sample". Journal of Psychopharmacology. 35 (3): 279–283. doi:10.1177/0269881121991567. ISSN 1461-7285. PMID 33579175. S2CID 231911366.
  18. Taylor, David; Vallianatou, Kalliopi; Whiskey, Eromona; Dzahini, Olubanke; MacCabe, James (14 March 2022). "Distinctive pattern of neutrophil count change in clozapine-associated, life-threatening agranulocytosis". Schizophrenia. 8 (1): 21. doi:10.1038/s41537-022-00232-0. ISSN 2334-265X. PMC 8920060. PMID 35288577.
  19. Horowitz, Mark Abie; Taylor, David (June 2019). "Tapering of SSRI treatment to mitigate withdrawal symptoms". The Lancet Psychiatry. 6 (6): 538–546. doi:10.1016/s2215-0366(19)30032-x. ISSN 2215-0366. PMID 30850328. S2CID 73507008.
  20. Horowitz, Mark Abie; Taylor, David (27 April 2022). "Distinguishing relapse from antidepressant withdrawal: clinical practice and antidepressant discontinuation studies". BJPsych Advances. 28 (5): 297–311. doi:10.1192/bja.2021.62. ISSN 2056-4678. S2CID 251885585.
  21. Horowitz, Mark Abie; Murray, Robin M.; Taylor, David (5 August 2020). "Tapering Antipsychotic Treatment". JAMA Psychiatry. 78 (2): 125–126. doi:10.1001/jamapsychiatry.2020.2166. PMID 32777027. S2CID 225366466.
  22. Horowitz, Mark Abie; Jauhar, Sameer; Natesan, Sridhar; Murray, Robin M; Taylor, David (23 March 2021). "A Method for Tapering Antipsychotic Treatment That May Minimize the Risk of Relapse". Schizophrenia Bulletin. 47 (sbab017): 1116–1129. doi:10.1093/schbul/sbab017. ISSN 0586-7614. PMC 8266572. PMID 33754644.
  23. Jenkins, James A.; Kontos, Nicholas (2016). "The Maudsley Prescribing Guidelines in Psychiatry, 12th ed". The Journal of Clinical Psychiatry. 77 (4): e469. doi:10.4088/JCP.16bk10716.
  24. Feetam, Celia (2006). "The Maudsley 2005–2006 Prescribing Guidelines (8th edn). David Taylor, Robert Kerwin & Carol Paton. London: Taylor & Francis, 2005, £19.95 pb, pp. 383. ISBN 1841845000". Psychiatric Bulletin. 30 (11): 437. doi:10.1192/pb.30.11.437-a. ISSN 0955-6036.
  25. "The Maudsley: prescribing guidelines (book review)". Pharmaceutical Journal.
  26. Jenkins, James (2016). "The Maudsley Prescribing Guidelines in psychiatry 12th Ed". Journal of Clinical Psychiatry. 77 (4): e469. doi:10.4088/JCP.16bk10716.
  27. "International Congress of the Royal College of Psychiatrists Programme 1st July- 4th July 2019". Retrieved 3 June 2021.
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