Daphnoretin

Daphnoretin is a protein kinase C activator isolated from Wikstroemia indica C.A. Mey, one of the 50 fundamental herbs in traditional Chinese medicine.[1][2] It has also been found to occur in Stellera chamaejasme - the single species in a genus closely related to Wikstroemia within the family Thymelaceae.[3]

Daphnoretin
Names
Preferred IUPAC name
7-Hydroxy-6-methoxy-3-[(2-oxo-2H-1-benzopyran-7-yl)oxy]-2H-1-benzopyran-2-one
Other names
Thymelol
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C19H12O7/c1-23-16-6-11-7-17(19(22)26-15(11)9-13(16)20)24-12-4-2-10-3-5-18(21)25-14(10)8-12/h2-9,20H,1H3
    Key: JRHMMVBOTXEHGJ-UHFFFAOYSA-N
  • InChI=1/C19H12O7/c1-23-16-6-11-7-17(19(22)26-15(11)9-13(16)20)24-12-4-2-10-3-5-18(21)25-14(10)8-12/h2-9,20H,1H3
    Key: JRHMMVBOTXEHGJ-UHFFFAOYAG
  • COC1=C(C=C2C(=C1)C=C(C(=O)O2)OC3=CC4=C(C=C3)C=CC(=O)O4)O
Properties
C19H12O7
Molar mass 352.298 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References
  1. Gu, Shoubin; He, Jinhai (January 9, 1012). "Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells". Molecules. MDPI. 17 (1): 598–612. doi:10.3390/molecules17010598. PMC 6268824. PMID 22231496.
  2. Ko, Feng N.; Chang, Ya L.; Kuo, Yueh H.; Lin, Yun L.; Teng, Che M. (October 1, 1993). "Daphnoretin, a new protein kinase C activator isolated from Wikstroemia indica C.A. Mey". Biochemical Journal. Portland Press Limited. 295 (1): 321–327. doi:10.1042/bj2950321. PMC 1134857. PMID 8216237.
  3. Medicinal Plants in Mongolia pub. World Health Organization, Regional Office for the Western Pacific Region 2013 ISBN 978 92 9061 632 0
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