DIS3L2

DIS3 mitotic control homolog (S. cerevisiae)-like 2 is a protein in humans that is encoded by the DIS3L2 gene.[5] The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012].

DIS3L2
Identifiers
Aliases	DIS3L2, FAM6A, PRLMNS, hDIS3 like 3'-5' exoribonuclease 2
External IDs	OMIM: 614184 MGI: 2442555 HomoloGene: 62417 GeneCards: DIS3L2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 231,961,245 bp[1] End 232,344,350 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C5 Start 86,631,530 bp[2] End 86,977,817 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve sperm right uterine tube right lobe of thyroid gland Achilles tendon left lobe of thyroid gland bone marrow cells skin of abdomen ganglionic eminence canal of the cervix Top expressed in spermatid hand spermatocyte mirror neural tube proximal tubule lip visual cortex otolith organ superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function 3'-5'-exoribonuclease activity poly(U) RNA binding metal ion binding ribonuclease activity protein binding RNA binding nuclease activity exonuclease activity hydrolase activity magnesium ion binding Cellular component cytoplasm polysome P-body exosome (RNase complex) Biological process miRNA catabolic process nucleic acid phosphodiester bond hydrolysis nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' cell division stem cell population maintenance rRNA processing cell cycle mitotic sister chromatid separation negative regulation of cell population proliferation RNA phosphodiester bond hydrolysis, exonucleolytic RNA phosphodiester bond hydrolysis nuclear-transcribed mRNA catabolic process, exonucleolytic polyuridylation-dependent mRNA catabolic process mitotic cell cycle RNA catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 129563 208718 Ensembl ENSG00000144535 ENSMUSG00000053333 UniProt Q8IYB7 Q8CI75 RefSeq (mRNA) NM_001257281 NM_001257282 NM_152383 NM_001172157 NM_153530 RefSeq (protein) NP_001244210 NP_001244211 NP_689596 NP_001165628 NP_705758 Location (UCSC) Chr 2: 231.96 – 232.34 Mb Chr 1: 86.63 – 86.98 Mb PubMed search [3] [4]
Wikidata
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