DDX1
ATP-dependent RNA helicase DDX1 is an enzyme that in humans is encoded by the DDX1 gene.[5][6]
Function
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin.[6]
Interactions
DDX1 has been shown to interact with HNRPK.[7] DDX1 has also been tentatively shown to interact with hCLE/C14orf166/RTRAF and HSPC117 in a cap-binding complex that activates mRNA translation. [8]
References
- GRCh38: Ensembl release 89: ENSG00000079785 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000037149 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Schmid SR, Linder P (February 1992). "D-E-A-D protein family of putative RNA helicases". Molecular Microbiology. 6 (3): 283–91. doi:10.1111/j.1365-2958.1992.tb01470.x. PMID 1552844. S2CID 45727289.
- "Entrez Gene: DDX1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1".
- Chen HC, Lin WC, Tsay YG, Lee SC, Chang CJ (October 2002). "An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K" (PDF). The Journal of Biological Chemistry. 277 (43): 40403–9. doi:10.1074/jbc.M206981200. PMID 12183465. S2CID 25252628.
- Cho WJ, Yoon WJ, Moon CH, Cha SJ, Song H, Cho HR, Jang SJ, Chung DK, Jeong CS, Park JW (November 2002). "Molecular cloning of a novel chaperone-like protein induced by rhabdovirus infection with sequence similarity to the bacterial extracellular solute-binding protein family 5". The Journal of Biological Chemistry. 277 (44): 41489–96. doi:10.1074/jbc.M207104200. PMID 12183466.
Further reading
- Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.
- Godbout R, Squire J (August 1993). "Amplification of a DEAD box protein gene in retinoblastoma cell lines". Proceedings of the National Academy of Sciences of the United States of America. 90 (16): 7578–82. Bibcode:1993PNAS...90.7578G. doi:10.1073/pnas.90.16.7578. PMC 47185. PMID 7689221.
- Kitajima Y, Yatsuki H, Zhang R, Matsuhashi S, Hori K (March 1994). "A novel human homologue of a dead-box RNA helicase family". Biochemical and Biophysical Research Communications. 199 (2): 748–54. doi:10.1006/bbrc.1994.1292. PMID 8135819.
- Akiyama K, Akao Y, Yokoyama M, Nakagawa Y, Noguchi T, Yagi K, Nishi Y (April 1999). "Expression of two dead box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines". Biochemistry and Molecular Biology International. 47 (4): 563–8. doi:10.1080/15216549900201603. PMID 10319407. S2CID 45609314.
- Golembowski S, Gellrich S, von Zimmermann M, Rutz S, Lippert S, Audring H, Lorenz P, Sterry W, Jahn S (April 2000). "Clonal evolution in a primary cutaneous follicle center B cell lymphoma revealed by single cell analysis in sequential biopsies". Immunobiology. 201 (5): 631–44. doi:10.1016/s0171-2985(00)80080-7. PMID 10834319.
- Bléoo S, Sun X, Hendzel MJ, Rowe JM, Packer M, Godbout R (October 2001). "Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA". Molecular Biology of the Cell. 12 (10): 3046–59. doi:10.1091/mbc.12.10.3046. PMC 60154. PMID 11598190.
- Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
- Chen HC, Lin WC, Tsay YG, Lee SC, Chang CJ (October 2002). "An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K" (PDF). The Journal of Biological Chemistry. 277 (43): 40403–9. doi:10.1074/jbc.M206981200. PMID 12183465. S2CID 25252628.
- Fang J, Kubota S, Yang B, Zhou N, Zhang H, Godbout R, Pomerantz RJ (December 2004). "A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev". Virology. 330 (2): 471–80. doi:10.1016/j.virol.2004.09.039. PMID 15567440.
- Krishnan V, Zeichner SL (December 2004). "Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication". Retrovirology. 1: 42. doi:10.1186/1742-4690-1-42. PMC 543576. PMID 15588285.
- Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
- Fang J, Acheampong E, Dave R, Wang F, Mukhtar M, Pomerantz RJ (June 2005). "The RNA helicase DDX1 is involved in restricted HIV-1 Rev function in human astrocytes". Virology. 336 (2): 299–307. doi:10.1016/j.virol.2005.03.017. PMID 15892970.
- Kaneko S, Ohira M, Nakamura Y, Isogai E, Nakagawara A, Kaneko M (March 2007). "Relationship of DDX1 and NAG gene amplification/overexpression to the prognosis of patients with MYCN-amplified neuroblastoma". Journal of Cancer Research and Clinical Oncology. 133 (3): 185–92. doi:10.1007/s00432-006-0156-y. PMID 17028906. S2CID 9295969.
- Tu LC, Yan X, Hood L, Lin B (April 2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells". Molecular & Cellular Proteomics. 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.
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