D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase

D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase (EC 2.7.7.70, D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase, D-glycero-D-manno-heptose-1beta-phosphate adenylyltransferase, hldE (gene), rfaE (gene)) is an enzyme with systematic name ATP:D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

D-glycero-beta-D-manno-heptose 1-phosphate + ATP ADP-D-glycero-beta-D-manno-heptose + diphosphate
D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase
Identifiers
EC no.2.7.7.70
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose.

References
  1. Valvano MA, Marolda CL, Bittner M, Glaskin-Clay M, Simon TL, Klena JD (January 2000). "The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose". Journal of Bacteriology. 182 (2): 488–97. doi:10.1128/jb.182.2.488-497.2000. PMC 94300. PMID 10629197.
  2. Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P (January 2002). "Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli". Journal of Bacteriology. 184 (2): 363–9. doi:10.1128/jb.184.2.363-369.2002. PMC 139585. PMID 11751812.
  3. Valvano MA, Messner P, Kosma P (July 2002). "Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides". Microbiology. 148 (Pt 7): 1979–89. doi:10.1099/00221287-148-7-1979. PMID 12101286.
  4. Wang L, Huang H, Nguyen HH, Allen KN, Mariano PS, Dunaway-Mariano D (February 2010). "Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB)". Biochemistry. 49 (6): 1072–81. doi:10.1021/bi902018y. PMC 2844805. PMID 20050615.
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