Cysteine-S-conjugate N-acetyltransferase
In enzymology, a cysteine-S-conjugate N-acetyltransferase (EC 2.3.1.80) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + an S-substituted L-cysteine CoA + an S-substituted N-acetyl-L-cysteine
| cysteine-S-conjugate N-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.80 | ||||||||
| CAS no. | 81725-80-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are acetyl-CoA and S-substituted L-cysteine, whereas its two products are CoA and S-substituted N-acetyl-L-cysteine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:S-substituted L-cysteine N-acetyltransferase. This enzyme participates in glutathione metabolism.
References
- Duffel MW, Jakoby WB (1982). "Cysteine S-conjugate N-acetyltransferase from rat kidney microsomes". Mol. Pharmacol. 21 (2): 444–8. PMID 6892478.
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